| Wk 24 | Wk 48 | |||||
|---|---|---|---|---|---|---|
| PBO† | 2 mg QD | 4 mg QD | PBO/4 mg QD† | 2 mg QD | 4 mg QD | |
| Linear extrapolation | ||||||
| Change in (D) mTSS | 0.72 | 0.27* | 0.25* | 1.36 | 0.43** | 0.45** |
| D Erosion | 0.43 | 0.20* | 0.17* | 0.82 | 0.31** | 0.32** |
| D JSN | 0.29 | 0.08* | 0.08* | 0.55 | 0.12* | 0.13* |
| D mTSS ≤0, n (%) | 150 (78) | 169 (81) | 167 (84) | 150 (78) | 175 (80) | 169 (83) |
| D mTSS ≤0.5, n (%) | 157 (82) | 179 (86) | 175 (88) | 150 (78) | 183 (84) | 174 (85) |
| D mTSS ≤SDC, n (%) | 165 (86) | 188 (90) | 186 (94)* | 162 (84) | 195 (89) | 186 (91)* |
| Observed/LOCF | ||||||
| D mTSS | 0.57 | 0.26* | 0.25* | 0.69 | 0.41 | 0.32* |
| D Erosion | 0.36 | 0.18* | 0.17* | 0.43 | 0.24 | 0.23* |
| D JSN | 0.21 | 0.08* | 0.08* | 0.26 | 0.17 | 0.10 |
| D mTSS ≤0, n (%) | 152 (78) | 169 (81) | 169 (85) | 151 (74) | 172 (79) | 169 (82) |
| D mTSS ≤0.5, n (%) | 163 (83) | 183 (87) | 178 (89) | 166 (81) | 188 (86) | 179 (87) |
| D mTSS ≤SDC, n (%) | 171 (87) | 192 (91) | 188 (94)* | 182 (89) | 205 (94) | 193 (94) |
Data are least squares mean change from baseline, unless otherwise stated; †Pts were switched to treatment with bari at rescue or at Wk 24. SDC: smallest detectable change. Wk 24 SDC=1.1; Wk 48 SDC=1.7; Comparisons analyzed using ANCOVA; *p≤0.05, **p≤0.01 vs. PBO.