Table 1.

HLA frequencies in patient with systemic sclerosis with ILD and without ILD compared to healthy controls

HLA alleles	SSc_Total	ILD(+)SSc	ILD(−)SSc	Control	SSc Total vs. Control	ILD(+)SSc vs. Control	ILD(−)SSc vs. Control

	(N=170)	(n=105)	(n=65)	(N=201)	P_c	P_c	P_c

B*52:01	23 (13.5)	20 (19.0)	3 (4.6)	9 (4.5)	0.076	<0.001	1.000
C*12:02	23 (13.5)	20 (19.0)	3 (4.6)	9 (4.5)	0.046	<0.001	1.000
DRB1* 15:02	29 (17.1)	24 (22.9)	5 (7.7)	14 (7.0)	0.074	<0.001	1.000
DPB1* 09:01	22 (12.9)	18 (17.1)	4 (6.2)	9 (4.5)	0.045	<0.001	1.000
DPB1* 13:01	52 (30.6)	38 (36.2)	14 (21.5)	25 (12.4)	<0.001	<0.001	1.000

Abbreviation: HLA, human leukocyte antigen; SSc, systemic sclerosis; ILD, interstitial lung disease; OR, odds ratio; P_c, corrected P by Bonferroni correction. P_c of ILD(+)SSc vs. ILD(−)SSc: HLA-B*52:01 (P_c=0.304), C*12:02 (P_c=0.184), DRB1*15:02 (P_c=0.407), DPB1*09:01 (P_c=0.570), DPB1*13:01 (P_c=0.660).