Table 1.

Median % or change from baseline to 12 wks in select biomarkers by treatment group

		N	BI 655064	Placebo	p-value*

Change in	% CD19+CD27+IgD+CD95+	28/15	−16.8	−8.0	0.0831
Change in	% CD19+CD27+IgD-CD95+	28/15	−15.3	+2.3	0.0765
Change in	% CD19+CD27-IgD-CD95+	28/15	−14.6	+4.0	0.0097
% change in	IgG ACPA	35/19	−19	−11.9	0.2771
% change in	IgG RF	35/17	−22.7	+14.3	0.0018
% change in	IgA RF	35/17	−13.9	0	0.0050
% change in	Total IgG	34/18	−8.6	−0.6	0.0082
% change in	Total IgM	34/18	−12.3	−0.3	0.0002
% change in	CD40L	34/17	−47.2	−59.6	0.9920
% change in	IL-6	34/18	−17.3	+18.7	0.1001
% change in	MMP-3	34/18	−7.8	+2.3	0.1574
% change in	RANKL	35/19	−29.4	0	0.0041