Changes in pulmonary function test after 1 year
| Limited ILD (n=42) | Extensive ILD (n=37) | Difference with 95%>CI | P-value† | |||||
|---|---|---|---|---|---|---|---|---|
| Baseline | 1 year | Δ* | Baseline | 1 year | Δ* | |||
| FVC | 91 (78–104) | 94 (82–109) | 2.9±13 | 80 (66–92) | 82 (63–95) | 2.0±9 | 0.9 (−4.7–6.4) | 0.76 |
| DLCO | 51 (39–60) | 47 (41–60) | −1.4±11 | 39 (31–51) | 41 (32–52) | 1.3±6 | −2.6 (−7.6–2.4) | 0.29 |
| Last observation carried forward | ||||||||
| FVC | 88 (75–102) | 93 (81–108) | 2.4±13 | 80 (66–92) | 82 (65–93) | 0.8±9 | 1.6 (−3.8–7.0) | 0.56 |
| DLCO | 51 (39–60) | 48 (41–59) | −1.5±11 | 39 (31–51) | 39 (29–50) | 0.04±6 | −1.6 (−6.1–3.0) | 0.50 |
| Per protocol analysis | ||||||||
| FVC | 83 (74–100) | 90 (80–106) | 2.3±13 | 83 (68–92) | 83 (66–98) | 3.0±9 | −0.7 (−7.5–6.1) | 0.83 |
| DLCO | 50 (40–60) | 48 (41–60) | 0.7±11 | 41 (32–55) | 40 (31–57) | 2.3±7 | −1.6 (−7.6–4.4) | 0.59 |
Values are the median of %> predicted (p25–75); *mean ± SD; Δ: difference between baseline and 1 year; CI: confidence interval. †Significance of the degree of change in the limited ILD group versus the extensive ILD group at 1 year; FVC: forced vital capacity; DLCO: diffusing capacity of the lung for carbon monoxide.