| RA-BEAM, RA-BUILD, RA-BEACON combined | ||
|---|---|---|
| Efficacy measure† | Continued bari 4 mg | Stepped down to bari 2 mg |
| Wk12 | (N=147) | (N=146) |
| CDAI LDA ≤10§, n (%) | 136 (92.5) | 123 (84.2)* |
| CDAI remission ≤2.8§, n (%) | 57 (38.8) | 54 (37.0) |
| ΔCDAI | 0.60 (3.44) | 2.04 (6.29)* |
| ΔTJC 68 | 0.3 (3.0) | 1.2 (3.8)* |
| ΔSJC 66 | 0.1 (1.7) | 0.8 (2.7)* |
| ΔHAQ-DI | 0.04 (0.26) | 0.06 (0.28) |
| ΔPain | 0.7 (14.7) | 2.5 (16.4) |
| ΔPtGA | 1.2 (14.3) | 2.5 (14.5) |
| ΔPhGA | −0.0 (9.6) | 2.7 (13.6)* |
| ΔCRP | 0.68 (7.16) | 1.68 (7.82) |
| ΔDAS28-CRP | 0.14 (0.70) | 0.36 (0.77)* |
| ΔDAS28-ESR | 0.10 (0.73) | 0.35 (0.89)* |
| ΔSDAI | 0.69 (3.55) | 2.19 (6.33)* |
†Values other than CDAI LDA or remission are mean change from baseline (SD) with missing data imputed using modified last observation carried forward; §Missing data imputed using nonresponder imputation; RA-BEAM = MTX-IR pts; RA-BUILD = csDMARD-IR pts; RA-BEACON = bDMARD-IR pts; Δ = change from baseline; CDAI = Clinical Disease Activity Index; CRP = C-reactive protein; DAS28 = Disease Activity Score modified to include the 28 diarthrodial joint count; ESR = erythrocyte sedimentation rate; HAQ-DI = Health Assessment Questionnaire-Disability Index; PhGA = Physician's Global Assessment of Disease Activity; PtGA = Patient's Global Assessment of Disease Activity; SD = standard deviation; SDAI=Simplified Disease Activity Index; SJC = swollen joint count based on 66 joints; TJC = tender joint count based on 68 joints; *p≤0.05 vs. bari 4 mg.