Association between anti-CarP antibody positivity and HAQ and DAS28
| Total cohort β (95% CI) | ACPA +ve β (95% CI) | ACPA −ve β (95% CI) | |
|---|---|---|---|
| HAQ | |||
| Univariate | 0.21 (0.14 to 0.29)** | 0.10 (−0.04 to 0.24) | 0.18 (0.04 to 0.32)* |
| Multivariate† | 0.12 (0.02 to 0.21)* | 0.09 (−0.05 to 0.23) | 0.14 (0.01 to 0.27)* |
| DAS28 | |||
| Univariate | 0.38 (0.26 to 0.50)** | 0.23 (0.01 to 0.46)* | 0.11 (−0.11 to 0.34) |
| Multivariate*† | 0.23 (0.07 to 0.39)* | 0.25 (0.03 to 0.48)* | 0.18 (−0.03 to 0.40) |
*p<0.05.
**p<0.001.
†Adjusted for age, gender, smoking status, polynomials of disease duration and year of recruitment.
+ve, positive, −ve, negative; ACPA, anticitrullinated protein antibodies; anti-CarP, anticarbamylated protein; DAS28, 28 joint disease activity score; HAQ, Health Assessment Questionnaire.