Subphenotypes | N | MAF | Pos vs Control | Pos vs Neg | ||||||
---|---|---|---|---|---|---|---|---|---|---|
Group | Pos | Neg | Pos | Neg | Control | p Value | OR (95% CI) | p Value | OR (95% CI) | |
Malar rash | EA | 2108 | 1171 | 0.088 | 0.087 | 0.099 | 0.11 | 0.89 (0.78 to 1.03) | 0.92 | 1.01 (0.85 to 1.21) |
AA | 685 | 714 | 0.08 | 0.066 | 0.086 | 0.24 | 0.87 (0.69 to 1.10) | 0.15 | 1.24 (0.92 to 1.65) | |
HS | 836 | 572 | 0.03 | 0.032 | 0.051 | 3.0×10−3 | 0.57 (0.39 to 0.83) | 0.62 | 0.89 (0.57 to 1.40) | |
Meta | 5.7×10−3 | 0.85 | 0.52 | 1.05 | ||||||
Discoid rash | EA | 573 | 2486 | 0.088 | 0.088 | 0.099 | 0.38 | 0.91 (0.73 to 1.13) | 0.98 | 1.00 (0.80 to 1.25) |
AA | 485 | 915 | 0.088 | 0.065 | 0.086 | 0.81 | 0.97 (0.75 to 1.25) | 0.029 | 1.39 (1.04 to 1.86) | |
HS | 180 | 1227 | 0.026 | 0.031 | 0.051 | 0.032 | 0.46 (0.22 to 0.93) | 0.43 | 0.75 (0.37 to 1.53) | |
Meta | 0.2 | 0.9 | 0.26 | 1.1 | ||||||
Photosensitivity | EA | 2345 | 1142 | 0.091 | 0.08 | 0.099 | 0.29 | 0.93 (0.82 to 1.06) | 0.16 | 1.14 (0.95 to 1.36) |
AA | 685 | 712 | 0.078 | 0.069 | 0.086 | 0.14 | 0.84 (0.66 to 1.06) | 0.39 | 1.14 (0.85 to 1.52) | |
HS | 840 | 564 | 0.037 | 0.022 | 0.051 | 0.047 | 0.70 (0.49 to 0.99) | 0.05 | 1.64 (1.00 to 2.67) | |
Meta | 0.029 | 0.89 | 0.031 | 1.17 | ||||||
Oral ulcers | EA | 1574 | 1642 | 0.09 | 0.09 | 0.099 | 0.22 | 0.91 (0.78 to 1.06) | 0.9 | 0.99 (0.83 to 1.17) |
AA | 495 | 903 | 0.059 | 0.081 | 0.086 | 1.7×10−3 | 0.63 (0.47 to 0.84) | 0.06 | 0.74 (0.54 to 1.01) | |
HS | 562 | 844 | 0.036 | 0.027 | 0.051 | 0.094 | 0.71 (0.48 to 1.06) | 0.2 | 1.33 (0.85 to 2.08) | |
Meta | 3.5×10−3 | 0.83 | 0.59 | 0.96 | ||||||
Arthritis | EA | 2987 | 619 | 0.088 | 0.091 | 0.099 | 0.075 | 0.89 (0.79 to 1.01) | 0.76 | 0.97 (0.78 to 1.20) |
AA | 1166 | 232 | 0.076 | 0.059 | 0.086 | 0.048 | 0.82 (0.67 to 1.01) | 0.19 | 1.33 (0.87 to 2.02) | |
HS | 1007 | 402 | 0.031 | 0.031 | 0.051 | 3.7×10−3 | 0.60 (0.42 to 0.85) | 0.96 | 1.01 (0.62 to 1.66) | |
Meta | 9.9×10−4 | 0.84 | 0.76 | 1.03 | ||||||
Serositis | EA | 1341 | 2060 | 0.084 | 0.092 | 0.099 | 0.042 | 0.85 (0.72 to 0.99) | 0.26 | 0.91 (0.76 to 1.08) |
AA | 653 | 742 | 0.07 | 0.076 | 0.086 | 0.025 | 0.75 (0.59 to 0.96) | 0.55 | 0.92 (0.69 to 1.22) | |
HS | 384 | 877 | 0.029 | 0.03 | 0.051 | 0.022 | 0.56 (0.34 to 0.92) | 0.94 | 0.98 (0.58 to 1.64) | |
Meta | 6.0×10−4 | 0.8 | 0.21 | 0.91 | ||||||
Renal disorder | EA | 1102 | 2143 | 0.079 | 0.098 | 0.099 | 0.016 | 0.80 (0.67 to 0.96) | 0.018 | 0.80 (0.67 to 0.96) |
AA | 697 | 701 | 0.065 | 0.081 | 0.086 | 6.1×10−3 | 0.71 (0.55 to 0.91) | 0.092 | 0.78 (0.58 to 1.04) | |
HS | 644 | 746 | 0.032 | 0.028 | 0.051 | 0.029 | 0.64 (0.43 to 0.96) | 0.41 | 1.21 (0.77 to 1.91) | |
Meta | 4.4×10−5 | 0.75 | 0.013 | 0.83 | ||||||
Neurological disorder | EA | 575 | 2524 | 0.099 | 0.092 | 0.099 | 0.89 | 1.02 (0.82 to 1.26) | 0.51 | 1.07 (0.87 to 1.33) |
AA | 372 | 1025 | 0.088 | 0.068 | 0.086 | 0.75 | 0.95 (0.72 to 1.27) | 0.069 | 1.34 (0.98 to 1.82) | |
HS | 194 | 1213 | 0.024 | 0.032 | 0.051 | 0.036 | 0.47 (0.23 to 0.95) | 0.42 | 0.75 (0.37 to 1.52) | |
Meta | 0.58 | 0.95 | 0.18 | 1.12 | ||||||
Haematological disorder | EA | 2173 | 1081 | 0.085 | 0.089 | 0.099 | 0.038 | 0.87 (0.76 to 0.99) | 0.67 | 0.96 (0.80 to 1.15) |
AA | 1011 | 384 | 0.07 | 0.079 | 0.086 | 0.012 | 0.76 (0.62 to 0.94) | 0.45 | 0.89 (0.65 to 1.22) | |
HS | 811 | 459 | 0.031 | 0.028 | 0.051 | 9.6×10−3 | 0.61 (0.42 to 0.89) | 0.79 | 1.07 (0.65 to 1.77) | |
Meta | 1.9×10−4 | 0.81 | 0.53 | 0.95 | ||||||
Anti-dsDNA | EA | 1179 | 1500 | 0.071 | 0.104 | 0.099 | 6.6×10−4 | 0.73 (0.61 to 0.88) | 1.2×10−4 | 0.68 (0.56 to 0.83) |
AA | 675 | 746 | 0.067 | 0.083 | 0.086 | 9.7×10−3 | 0.72 (0.56 to 0.92) | 0.097 | 0.79 (0.59 to 1.04) | |
HS | 726 | 564 | 0.03 | 0.028 | 0.051 | 7.1×10−3 | 0.58 (0.39 to 0.86) | 0.61 | 1.13 (0.70 to 1.84) | |
Meta | 7.6×10−7 | 0.71 | 1.9×10−4 | 0.75 | ||||||
Anti-Sm | EA | 225 | 2064 | 0.109 | 0.093 | 0.099 | 0.37 | 1.15 (0.85 to 1.56) | 0.24 | 1.20 (0.88 to 1.64) |
AA | 430 | 755 | 0.087 | 0.076 | 0.086 | 0.78 | 0.96 (0.74 to 1.26) | 0.41 | 1.14 (0.84 to 1.54) | |
HS | 294 | 905 | 0.03 | 0.029 | 0.051 | 0.069 | 0.60 (0.35 to 1.04) | 0.71 | 1.11 (0.63 to 1.98) | |
Meta | 0.78 | 0.97 | 0.15 | 1.16 | ||||||
Anti-RNP | EA | 255 | 1382 | 0.104 | 0.095 | 0.099 | 0.46 | 1.12 (0.83 to 1.51) | 0.49 | 1.12 (0.82 to 1.53) |
AA | 378 | 253 | 0.078 | 0.077 | 0.086 | 0.34 | 0.87 (0.65 to 1.16) | 0.91 | 1.03 (0.67 to 1.57) | |
HS | 171 | 443 | 0.024 | 0.04 | 0.051 | 0.033 | 0.44 (0.21 to 0.94) | 0.16 | 0.57 (0.26 to 1.26) | |
Meta | 0.45 | 0.93 | 0.86 | 1.02 | ||||||
Anti-SSA/Ro | EA | 450 | 1331 | 0.086 | 0.093 | 0.099 | 0.28 | 0.87 (0.68 to 1.12) | 0.51 | 0.92 (0.70 to 1.19) |
AA | 292 | 542 | 0.062 | 0.08 | 0.086 | 0.023 | 0.66 (0.46 to 0.94) | 0.21 | 0.77 (0.51 to 1.15) | |
HS | 238 | 491 | 0.028 | 0.039 | 0.051 | 0.027 | 0.51 (0.28 to 0.93) | 0.28 | 0.70 (0.36 to 1.34) | |
Meta | 5.4×10−3 | 0.76 | 0.13 | 0.85 | ||||||
Anti-SSB/La | EA | 148 | 1506 | 0.091 | 0.095 | 0.099 | 0.76 | 0.94 (0.62 to 1.41) | 0.87 | 0.97 (0.64 to 1.46) |
AA | 81 | 692 | 0.037 | 0.08 | 0.086 | 0.025 | 0.39 (0.17 to 0.89) | 0.057 | 0.44 (0.19 to 1.03) | |
HS | 71 | 558 | 0.042 | 0.033 | 0.051 | 0.63 | 0.81 (0.34 to 1.92) | 0.53 | 1.33 (0.54 to 3.30) | |
Meta | 0.18 | 0.79 | 0.5 | 0.89 |
N, number in sample; MAF, minor allele frequency; Pos, subphenotype positive; Neg, subphenotype negative; p value, p value and OR were calculated using a logistic regression model adjusted for gender and global ancestry; EA, European–American; AA, African–American; HS, Hispanic; Meta, Meta-analysis; SLE, systemic lupus erythematosus. p Values ≤0.05 are marked with bold italics; significant p values after Bonferroni correction were ≤3.6×10−3.