IHC of synovial biopsy tissue
| % Change in IHC score Day -7 to Day 28 | p Value (tofacitinib vs placebo) | ||
|---|---|---|---|
| Tofacitinib 10 mg BID, % (N) | Placebo, % (N) | ||
| CD3+ T cell | 1.59 (10) | 0.02 (8) | 0.5811 |
| CD20+ B cell | 2.08 (10) | -1.68 (10) | 0.1748 |
| CD68+ sublining macrophage | 1.77 (12) | 0.71 (11) | 0.8605 |
See Methods, Synovial immunohistochemistry for description of image analysis methods.
BID, twice daily; IHC, immunohistochemistry; N, number of samples that were evaluated.