Telomere lengths are prematurely reduced in naïve CD4+ T cells of patients with aSpA and RA
| Age | HC | aSpA | RA | HC vs aSpA | HC vs RA | aSpA vs RA |
|---|---|---|---|---|---|---|
| PBMCs | ||||||
| −35 | 7.6 (5.8–8.3) | 6.1 (5.6–8.0) | 6.0 (5.6–8.2) | 0.018 | 0.101 | 0.604 |
| 35–45 | 6.7 (5.8–8.7) | 6.1 (5.7–7.6) | 6.7 (5.8–8.2) | 0.095 | 0.936 | 0.068 |
| 45–55 | 6.2 (5.4–6.5) | 6.4 (5.7–7.8) | 6.2 (5.7–6.2) | 0.403 | 0.156 | 0.206 |
| 55–65 | 6.3 (5.8–6.6) | 6.4 (6.0–7.0) | 5.8 (5.6–6.4) | 0.343 | 0.138 | 0.052 |
| 65- | 6.3 (6.0–6.4) | 6.3 (6.3–7.4) | 6.0 (5.2–6.4) | 0.629 | 0.099 | 0.028 |
| CD4+CD45RA+ | ||||||
| −35 | 7.1 (5.9–8.6) | 6.2 (5.7–7.6) | 6.0 (5.8–8.5) | 0.004 | 0.166 | 0.636 |
| 35–45 | 6.9 (5.7–8.7) | 6.0 (5.7–7.9) | 6.7 (5.8–8.4) | 0.067 | 0.979 | 0.019 |
| 45–55 | 6.3 (5.3–6.6) | 6.4 (5.7–8.1) | 6.2 (5.7–6.3) | 0.312 | 0.186 | 0.310 |
| 55–65 | 6.5 (5.7–6.8) | 6.4 (6.1–7.8) | 5.9 (5.6–6.5) | 0.755 | 0.138 | 0.030 |
| 65- | 6.1 (5.8–6.3) | 6.5 (6.4–6.7) | 6.1 (5.6–6.5) | 0.057 | 0.574 | 0.012 |
| CD8+CD45RA+ | ||||||
| −35 | 7.0 (5.9–8.5) | 6.1 (5.7–7.4) | 6.1 (5.4–8.0) | 0.018 | 0.232 | 0.429 |
| 35–45 | 6.4 (5.7–8.0) | 6.1 (5.3–7.5) | 6.6 (5.8–8.2) | 0.145 | 0.406 | 0.019 |
| 45–55 | 6.1 (5.6–6.5) | 6.3 (5.7–7.6) | 6.0 (5.6–6.3) | 0.349 | 0.405 | 0.178 |
| 55–65 | 6.1 (5.5–6.5) | 6.3 (6.1–7.6) | 5.9 (5.6–6.3) | 0.343 | 0.181 | 0.052 |
| 65- | 6.0 (5.9–6.2) | 6.4 (6.2–6.8) | 6.0 (5.5–6.5) | 0.057 | 0.897 | 0.072 |
| CD4+CD45RO+ | ||||||
| −35 | 7.0 (5.8–8.3) | 6.0 (5.5–8.5) | 5.9 (5.8–8.9) | 0.068 | 0.535 | 0.783 |
| 35–45 | 6.6 (5.5–7.1) | 5.9 (4.6–7.3) | 6.5 (5.8–8.4) | 0.072 | 0.327 | 0.004 |
| 45–55 | 6.0 (5.4–6.4) | 6.0 (5.6–7.6) | 6.0 (5.6–6.4) | 0.907 | 0.853 | 0.462 |
| 55–65 | 6.1 (5.7–6.5) | 6.4 (5.9–7.5) | 5.8 (5.6–6.2) | 0.570 | 0.086 | 0.045 |
| 65- | 6.0 (5.8–6.2) | 6.1 (5.5–6.3) | 5.9 (5.5–6.4) | 0.724 | 0.654 | 0.634 |
| CD8+CD45RO+ | ||||||
| −35 | 7.4 (5.8–8.1) | 6.1 (5.5–7.5) | 6.1 (5.7–8.0) | 0.010 | 0.145 | 0.435 |
| 35–45 | 6.6 (5.8–7.9) | 6.0 (5.7–7.3) | 6.7 (5.8–7.9) | 0.100 | 0.870 | 0.037 |
| 45–55 | 6.2 (5.7–6.6) | 6.4 (5.6–7.8) | 6.1 (5.8–6.2) | 0.380 | 0.195 | 0.270 |
| 55–65 | 6.1 (5.7–7.5) | 6.2 (6.1–7.6) | 5.9 (5.6–6.4) | 0.291 | 0.063 | 0.045 |
| 65- | 6.0 (5.8–6.2) | 6.3 (6.3–6.8) | 6.0 (4.7–6.7) | 0.034 | 0.654 | 0.030 |
Overview of median (range) telomere lengths (in kbp) in PBMCs and T-cell subsets of HCs, patients with aSpA and patients with RA subdivided into groups according to their age. aSpA, axial spondyloarthritis; PBMC, peripheral blood mononuclear cells; HC, healthy control; RA, rheumatoid arthritis.