Table 1

Associations of 9 ANTXR2 SNPs with AS in (1A) the independent replication study, (1B) HLA-B27-positive and (1C) HLA-B27-negative stratified analyses

Replication study
(A) All cases vs controls (2978 vs 8365)						(B) B27+ cases vs B27+ controls (1935 vs 696)			(C) B27– cases vs B27– controls (358 vs 7669)
SNP	Minor allele	MAF (%) cases/controls	p Value	OR	95% CI	p Value	OR	95% CI	p Value	OR	95% CI
rs6534639	C	45/47	0.0005*	0.90	0.85 to 0.95	0.09	0.90	0.79 to 1.02	0.01*	0.83	0.71 to 0.96
rs4234848	G	31/32	0.08	0.94	0.88 to 1.01	0.37	0.94	0.82 to 1.08	0.1	0.88	0.74 to 1.04
rs11098965	C	24/25	0.2	0.96	0.89 to 1.03	0.19	0.91	0.79 to 1.05	0.4	0.93	0.78 to 1.11
rs4444771	G	24/25	0.2	0.95	0.89 to 1.02	0.14	0.90	0.78 to 1.03	0.6	0.96	0.80 to 1.14
rs12504282	C	43/46	0.0001*	0.89	0.84 to 0.94	0.006*	0.84	0.74 to 0.95	0.4	0.93	0.80 to 1.08
rs10000471	C	33/35	0.01*	0.92	0.86 to 0.98	0.03*	0.87	0.76 to 0.99	0.1	0.88	0.75 to 1.04
rs4640621	A	34/36	0.001*	0.90	0.85 to 0.96	0.01*	0.85	0.75 to 0.97	1.0	1.00	0.85 to 1.17
rs4333130	G	34/36	0.002*	0.91	0.85 to 0.97	0.02*	0.86	0.75 to 0.98	1.0	1.00	0.85 to 1.17
rs6839672	A	16/15	0.6	1.02	0.94 to 1.11	0.10	1.16	0.97 to 1.38	0.3	0.90	0.72 to 1.12

Nominally significant (p<0.05) associations are shown (*).
Number of cases and controls in each analysis is also shown in brackets. (B27: HLA-B27).
HLA, human leukocyte antigen; MAF, minor allele frequency; SNP, single nucleotide polymorphism.