Joint-level associations of MRI erosion progression with osteitis and synovitis*
| Predictors of MRI erosion change >1.0 at week 52 (no. of erosion events/n; 11/1096) | OR (95% CI) | p Value |
|---|---|---|
| Model 1 | ||
| Baseline osteitis of matching joint | 2.10 (1.01 to 4.37) | 0.0467 |
| Baseline synovitis of matching joint | 3.34 (1.99 to 5.62) | <0.0001 |
| Osteitis worsening change at week 12 of matching joint | 7.96 (3.07 to 20.68) | <0.0001 |
| Synovitis worsening change at week 12 of matching joint | 1.46 (0.32 to 6.78) | 0.6278 |
| Model 2 | ||
| Baseline osteitis of matching joint | 2.13 (0.99 to 4.59) | 0.0528 |
| Baseline synovitis of matching joint | 2.76 (1.75 to 4.35) | <0.0001 |
| Osteitis worsening change at week 52 of matching joint | 4.43 (1.83 to 10.74) | 0.0010 |
| Synovitis worsening change at week 52 of matching joint | 1.01 (0.46 to 2.21) | 0.9769 |
*Models are logistic regressions to evaluate joint-level MRI erosion progression at week 52 with listed predictors, adjusted for correlation of joints within patients.
OR interpreted as the increased odds of erosion change >1 (ie, progression) at week 52 per 1 unit change in predictor, adjusting for the other effects. p value <0.05 indicates statistically significant increased risk of erosion change (progression).