Comparison of tool scores for the informative items used in clinical correlation analysis, in quadriceps and biceps biopsies
| Domain | Quadriceps (n=33) | Biceps (n=22) | p Value | |
|---|---|---|---|---|
| Inflammatory domain | Tool score | n (%) | n (%) | |
| CD3+ endomysial infiltration | 0 | 11 (33) | 11 (50) | |
| 1 | 14 (42) | 9 (41) | 0.27 | |
| 2 | 8 (24) | 2 (9) | ||
| CD3+ perimysial infiltration | 0 | 11 (33) | 12 (55) | |
| 1 | 12 (36) | 7 (32) | 0.22 | |
| 2 | 10 (30) | 3 (14) | ||
| CD68+ endomysial infiltration | 0 | 2 (6) | 3 (14) | |
| 1 | 8 (24) | 5 (23) | 0.63 | |
| 2 | 23 (70) | 14 (64) | ||
| Inflammatory domain total (modified), median (IQR) | Possible range 0–6 | 4 (1.5, 5) | 2.5 (1, 4) | 0.15 |
| Muscle fibre domain | ||||
| Perifascicular atrophy | 0 | 22 (67) | 6 (27) | |
| 1 | 0 (0) | 1 (5) | 0.01 | |
| 2 | 11 (33) | 15 (68) | ||
| Neonatal myosin | 0 | 9 (27) | 8 (36) | |
| 1 | 24 (73) | 14 (64) | 0.48 | |
| Regeneration/degeneration/necrosis: perifascicular | 0 | 20 (61) | 6 (27) | |
| 1 | 2 (6) | 1 (5) | 0.04 | |
| 2 | 11 (33) | 15 (68) | ||
| Muscle fibre domain total (modified), | Possible range 0–5 | 2 (0, 4) | 5 (1, 5) | 0.01 |
| Histopathologists' VAS, median (IQR) | Range 0–10 | 3.3 (1.1, 5.9) | 6.1 (2.2, 7.5) | 0.023 |
VAS, Visual Analogue Score.