Structural changes in the meniscal transection (MNX) and monosodium iodoacetate (MIA) animal models of osteoarthritis at day 20 and 35 after induction
| Structural changes | Day 20 | Day 35 | ||||
|---|---|---|---|---|---|---|
| MNX | MIA | Control | MNX | MIA | Control | |
| Cartilage damage score (range 0–15) | 9 (6–14)** | 15 (5–15)*** | 0 (0–1) | 7 (5–11)** | 12 (10–15)*** | 0 (0–1) |
| Osteophyte score (range 0–3) | 2 (1–2)* | 1 (1–2)* | 0 (0–0) | 3 (2–3)*** | 1 (1–2)* | 0 (0–0) |
| Number of channels crossing the medial osteochondral junction | 3 (3–6)* | 4 (4–5)** | 1 (0–2) | 4 (3–5)** | 4 (2–5) | 1 (0–2) |
| % Synovial macrophage infiltration | 4 (2–5)*** | 3 (2–5)*** | 1 (0–1) | 3 (2–4)*** | 2 (1–4)** | 1 (1–1) |
| Synovial inflammation grade (range 0–3) | 1 (1–1)** | 1 (1–1)** | 0 (0–0) | 1 (1–2)* | 1 (1–2)* | 1 (0–1) |
Values are the median (IQR) of n=8 animals/group.
*p<0.05, **p<0.01, ***p<0.001 versus controls.