Risk factors for erosive osteoarthritis compared to reference groups with non-erosive moderate–severe and severe radiographic hand osteoarthritis
| Exposure | Erosive osteoarthritis vs K&L≥3 | Erosive osteoarthritis vs K&L=4 |
|---|---|---|
| aOR (95% CI) | aOR (95% CI) | |
| Female gender | 1.4 (0.7 to 2.7) | 1.3 (0.6 to 3.1) |
| Manual occupation | 0.7 (0.4 to 1.2) | 0.7 (0.4 to 1.4) |
| Attended higher education | 1.6 (0.8 to 3.1) | 1.3 (0.6 to 3.0) |
| Family history of arthritis | 1.2 (0.7 to 2.1) | 1.4 (0.7 to 2.9) |
| Previous hand injury | 1.5 (0.8 to 2.7) | 1.5 (0.7 to 3.3) |
| Excessive hand use at work or in pastimes | 1.6 (0.8 to 3.2) | 1.7 (0.8 to 4.0) |
| BMI>30 kg/m2 | 1.1 (0.6 to 1.9) | 1.1 (0.5 to 2.1) |
| Type 2 diabetes or impaired fasting glucose | 0.6 (0.2 to 1.8) | 0.5 (0.2 to 1.8) |
| Hypertension | 1.2 (0.7 to 2.1) | 1.8 (0.9 to 3.5) |
| Dyslipidaemia | 4.7 (2.1 to 10.6) | 3.4 (1.2 to 9.6) |
| Prescribed a lipid-regulating drug | 1.2 (0.6 to 2.4) | 1.4 (0.6 to 3.2) |
| Metabolic syndrome* | 2.7 (1.0 to 7.1) | 3.2 (0.8 to 13.2) |
aOR, adjusted OR for age and gender; BMI, body mass index; K&L, Kellgren and Lawrence.
*Metabolic syndrome was defined as the presence of three or more of the following: BMI>30 kg/m2, hypertension, dyslipidaemia and type 2 diabetes or impaired fasting glucose.