Studies included in the TreatOA GWAS meta-analysis
| Study | N cases | N controls | λ | N SNPs | ROA/SOA | Controls | Genotyping platform | Imputation method |
|---|---|---|---|---|---|---|---|---|
| Discovery stage | ||||||||
| arcOGEN stage 1 | 1728 | 4896 | 1.058 | 2.454.242 | ROA/SOA | Population | Illumina Human610 (cases)+Illumina 1.2M Duo (controls) | Impute |
| deCODE | 1423 | 31 385 | 1.182 | 2.399.690 | SOA | Osteoarthritis-free | Infinium HumanHap 300+humanCNV370 | Impute |
| EGCUT | 64 | 2531 | 0.994 | 2.242.156 | ROA | Population | Illumina HumanCNV370 or HumanOmniExpress | Impute |
| GARP | 106 | 1671 | 1.294 | 2.406.007 | SOA/ROA | KL<2 | Illumina Infinium HD Human660W-Quad | Impute |
| RSI | 760 | 3233 | 1.009 | 2.450.385 | ROA | KL<2 | Illumina HumanHap550v3 | MACH |
| RSII | 159 | 1472 | 0.993 | 2.442.419 | ROA | KL<2 | Illumina HumanHap550-Duo | MACH |
| RSIII | 41 | 1487 | 0.962 | 2.397.764 | ROA | KL<2 | Illumina Human660W-Quad | MACH |
| TwinsUK | 68 | 228 | 0.993 | 2.358151 | ROA | KL<2 | Infinium HumanHap300 | Impute |
| Total discovery | 4349 | 46 903 | 1.028 | 2.567.279 | – | – | ||
| Replication stage | ||||||||
| arcOGEN stage 2 | 1763 | 6157 | 1.058 | – | ROA/SOA | – | Illumina Human610 (cases)+Illumina 1.2M Duo (controls) | Impute |
| SOF* | 761 | 2376 | 1.008 | – | ROA | – | Illumina Omni 1 array (1.1 million probes) | MACH |
| MrOS* | 446 | 2837 | 1.002 | – | ROA | – | Illumina Omni 1 array (1.1 million probes) | MACH |
| arcOGEN plus | 223 | 1828 | – | – | ROA/SOA | – | Illumina Human610 (cases)+Illumina 1.2M Duo (controls) | Impute |
| EGCUT | 977 | 1131 | – | – | ROA | – | Illumina HumanCNV370 or HumanOmniExpress | Impute |
| Greek TJR cases | 93 | 361 | – | – | SOA | – | Single base extension using SNaPshot Multiplex Kit (Applied Biosystems, Foster City, USA)) | – |
| Paprika Study | 602 | 2321 | – | – | SOA | – | Sequenom (MassARRAY iPLEX Gold) | – |
| Spanish TJR cases | 697 | 783 | – | – | SOA | – | Single base extension using SNaPshot Multiplex Kit (Applied Biosystems, Foster City, USA)) | – |
| Icelandic cases | 857 | 1857 | – | – | SOA | – | Centaurus (Nanogen)37 | |
| Swedish MDC study | 509 | 919 | – | – | SOA | – | Centaurus (Nanogen)37 | – |
| Total replication | 6928 | 20 570 | – | – | ||||
| Total | 11 277 | 67 473 | – | – | ||||
EGCUT, Estonian Genome Center, University of Tartu; GWAS, genome-wide association studies; HD, high density; KL, Kellgren-Lawrence score; MDC, Malmo Diet Cancer study; MrOS, Osteroporotic Fractures in Men study; ROA, radiographic osteoarthritis; SOA, symptomatic osteoarthritis; SOF, Study of Osteoporotic Fractures; TJR, total joint replacement.