Endothelial function and damage in SLE cases compared with controls
| SLE (n=27) | Control (n=22) | p Value | |
|---|---|---|---|
| Baseline BA diameter (mm) | 3.34 (3.10, 3.84) | 3.34 (3.12, 4.07) | 0.89 |
| % FMD (at 60 s) | 1.63 (−1.22, 5.32) | 5.49 (3.02, 8.57) | 0.04 |
| % FMD (maximum) | 2.86 (0.60, 5.32) | 6.81 (3.46, 8.57) | 0.03 |
| % GTN dilatation | 15.3 (11.9, 19.1) | 12.0 (10.3, 17.3) | 0.43 |
| FMD <5% (at 60 s) | 75% | 43% | 0.04 |
| EMP (n/ml) | 157548 (59906, 278775) | 41,025 (30179, 98082) | 0.001 |
| VCAM-1 (ng/ml) | 488 (348, 555) | 289 (272, 317) | <0.001 |
| VEGF (pg/ml) | 108 (57, 156) | 55 (42, 153) | 0.23 |
| sEPCR (ng/ml) | 49.3 (38.0, 67.3) | 43.2 (38.4, 63.3) | 0.06 |
Unless otherwise indicated, values are median (IQR).
BA, brachial artery; EMP, endothelial microparticle; FMD, flow-mediated dilatation; GTN, glyceryl trinitrate; sEPCR, soluble endothelial protein c receptor; VCAM-1, vascular cell adhesion molecule-1; VEGF, vascular endothelial growth factor.