Porphyromonas gingivalis peptidylarginine deiminase (PPAD) peptide sequences and the antibody response to these peptides in patients with rheumatoid arthritis (RA)
| PPAD peptide name | Sequence | Percentage positive RA sera* (n=20) |
|---|---|---|
| CPP1 | CQMQAD-Cit†-TNGQFATEEMQ-Cit-AFQETC | 20 |
| CPP2 | CPAGPV-Cit-AIAEYE-Cit-SAAVLV-Cit-YPFGC | 15 |
| CPP3 | CAKTDSYWT-Cit-DYTGWFAMYDC | 40 |
| CPP4 | CDFIYN-Cit-P-Cit-PNDDEFPKYC | 0 |
| CPP5 | CLAPNKILI-Cit-KVPDNHPQHC | 15 |
| CPP6 | CGTKYEVY-Cit-ALATNEQPYTC | 20 |
| CPP7 | CNSLILNN-Cit-VFVPVNGPASC | 0 |
| CPP8 | CLGTDALHC-Cit-THEVADKGC | 40 |
| CPP9 | CTISPVQCYY-Cit-INGSGSFKC | 0 |
| CPP10 | CSAADNSG-Cit-KETYPFIGEPC | 15 |
| CPP11 | CKAL-Cit-AWFNAG-Cit-SELAVSVC | 30 |
| CPP12 | CSLNIAGTY-Cit-IKLYNTAGEC | 30 |
| CPP13 | CYVLVVEGNGI-Cit-ETMKILKC | 20 |
*Values are the percentage positive based on the 95th percentile response of the control sample values at an OD450.
†Cit: The arginine residue has been substituted with citrulline.