ORs for disease risk in different subsets of rheumatoid arthritis in subjects exposed to different combinations of HLA-DRB1 shared epitope (SE), smoking and PTPN22 compared with non-exposed subjects
| CEP-1 /Cit-vim | HLA-DRB1 SE | Smoking | PTPN22 | Cases/controls | OR* | 95% CI |
|---|---|---|---|---|---|---|
| −/− | − | − | − | 106/178 | 1 | Ref |
| −/− | − | − | + | 41/49 | 1.4 | 0.9 to 2.3 |
| −/− | + | − | − | 168/200 | 1.4 | 1.0 to 1.9 |
| −/− | + | − | + | 47/43 | 2 | 1.2 to 3.2 |
| −/− | − | + | − | 140/233 | 1 | 0.8 to 1.4 |
| −/− | − | + | + | 61/81 | 1.4 | 0.9 to 2.1 |
| −/− | + | + | − | 223/252 | 1.6 | 1.1 to 2.1 |
| −/− | + | + | + | 76/61 | 2.4 | 1.5 to 3.6 |
| +/− | − | − | − | 4/178 | 1 | Ref |
| +/− | − | − | + | 2/49 | 1.9 | 0.3 to 10.7 |
| +/− | + | − | − | 32/200 | 7 | 2.4 to 20.3 |
| +/− | + | − | + | 18/43 | 20.1 | 6.4 to 63.2 |
| +/− | − | + | − | 13/233 | 2.6 | 0.8 to 8.2 |
| +/− | − | + | + | 10/81 | 5.7 | 1.7 to 18.8 |
| +/− | + | + | − | 80/252 | 15.4 | 5.5 to 43.1 |
| +/− | + | + | + | 29/61 | 24.4 | 8.2 to 73.1 |
| −/+ | − | − | − | 10/178 | 1 | Ref |
| −/+ | − | − | + | 4/49 | 1.7 | 0.5 to 5.7 |
| −/+ | + | − | − | 47/200 | 4.3 | 2.1 to 8.8 |
| −/+ | + | − | + | 22/43 | 9.9 | 4.3 to 22.8 |
| −/+ | − | + | − | 21/233 | 1.7 | 0.8 to 3.8 |
| −/+ | − | + | + | 4/81 | 1 | 0.3 to 3.3 |
| −/+ | + | + | − | 83/252 | 6.3 | 3.2 to 12.7 |
| −/+ | + | + | + | 33/61 | 11.5 | 5.3 to 25.3 |
| +/+ | − | − | − | 6/178 | 1 | Ref |
| +/+ | − | − | + | 5/49 | 3.4 | 1.0 to 11.7 |
| +/+ | + | − | − | 43/200 | 6.4 | 2.7 to 15.6 |
| +/+ | + | − | + | 40/43 | 30.4 | 12.0 to 76.9 |
| +/+ | − | + | − | 14/233 | 1.8 | 0.7 to 4.8 |
| +/+ | − | + | + | 7/81 | 2.7 | 0.9 to 8.2 |
| +/+ | + | + | − | 212/252 | 26.6 | 11.5 to 61.7 |
| +/+ | + | + | + | 92/61 | 50.1 | 20.6 to 121.8 |
↵* Adjusted for age, gender and residential area.