UK anti-CCP positive RA | UK anti-CCP negative RA | Comparison | |||||||||||
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Chr. | Locus Name | OR | 95% CI | p Value | N cases | N cont | OR | 95% CI | p Value | N cases | N cont | ORpos/ORneg | p Value |
1 | CD2/CD58 | 1.11 | 1.05 to 1.18 | 3.68E-04 | 3827 | 11468 | 1.05 | 0.97 to 1.13 | 0.242 | 1918 | 11468 | 1.06 | 0.183 |
1 | FCGR2A | 1.16 | 1.07 to 1.25 | 2.28E-04 | 3467 | 11468 | 1.08 | 0.96 to 1.20 | 0.195 | 1563 | 11468 | 1.08 | 0.241 |
1 | MMEL1/TNFRSF14 | 0.88 | 0.83 to 0.93 | 2.12E-05 | 3485 | 12394 | 0.97 | 0.89 to 1.05 | 0.426 | 1574 | 12394 | 0.91 | 0.045 |
1 | PTPN22 | 1.91 | 1.77 to 2.05 | 3.91E-65 | 3813 | 12398 | 1.20 | 1.07 to 1.33 | 1.34E-03 | 1894 | 12398 | 1.60 | 7.11E-15 |
1 | PTPRC | 0.91 | 0.84 to 0.99 | 0.022 | 3600 | 11427 | 0.96 | 0.86 to 1.08 | 0.504 | 1580 | 11427 | 0.94 | 0.384 |
2 | AFF3 locus 1 | 1.17 | 1.11 to 1.23 | 5.36E-09 | 3777 | 11832 | 1.05 | 0.98 to 1.13 | 0.165 | 1881 | 11832 | 1.11 | 0.008 |
2 | AFF3 locus 2 | 1.17 | 1.09 to 1.25 | 2.64E-06 | 2378 | 8425 | 1.06 | 0.97 to 1.17 | 0.187 | 991 | 8425 | 1.10 | 0.086 |
2 | CD28 | 1.18 | 1.12 to 1.26 | 3.15E-08 | 3826 | 11469 | 1.08 | 1.00 to 1.17 | 0.055 | 1912 | 11469 | 1.09 | 0.049 |
2 | CTLA4 | 0.91 | 0.87 to 0.96 | 9.32E-04 | 3626 | 11975 | 0.94 | 0.88 to 1.02 | 0.121 | 1592 | 11975 | 0.97 | 0.475 |
2 | REL | 1.13 | 1.07 to 1.20 | 1.58E-05 | 3196 | 10878 | 1.02 | 0.95 to 1.11 | 0.554 | 1437 | 10878 | 1.11 | 0.028 |
2 | SPRED2 | 0.91 | 0.86 to 0.97 | 3.69E-03 | 2706 | 9032 | 0.97 | 0.89 to 1.06 | 0.565 | 1132 | 9032 | 0.94 | 0.198 |
2 | STAT4 | 1.13 | 1.06 to 1.21 | 1.34E-04 | 3401 | 11822 | 1.11 | 1.02 to 1.20 | 0.015 | 1824 | 11822 | 1.02 | 0.656 |
3 | DNASE1L3/PXK | 1.13 | 1.02 to 1.24 | 0.014 | 3445 | 11486 | 0.93 | 0.80 to 1.08 | 0.338 | 1432 | 11486 | 1.21 | 0.020 |
4 | IL2/IL21 | 0.88 | 0.82 to 0.95 | 1.03E-03 | 3402 | 11767 | 0.95 | 0.86 to 1.04 | 0.264 | 1814 | 11767 | 0.93 | 0.211 |
4 | RBPJ | 1.14 | 1.07 to 1.21 | 1.98E-05 | 3195 | 10879 | 1.02 | 0.94 to 1.11 | 0.681 | 1434 | 10879 | 1.12 | 0.021 |
5 | ANKRD55/IL6ST | 0.85 | 0.78 to 0.92 | 9.62E-05 | 2377 | 8428 | 0.80 | 0.70 to 0.90 | 2.42E-04 | 991 | 8428 | 1.07 | 0.357 |
5 | GIN1/C5orf30 | 0.88 | 0.83 to 0.94 | 4.86E-05 | 3372 | 11260 | 0.88 | 0.80 to 0.95 | 2.32E-03 | 1410 | 11260 | 1.01 | 0.835 |
6 | CCR6 | 1.13 | 1.07 to 1.19 | 1.48E-05 | 3423 | 11313 | 0.99 | 0.92 to 1.07 | 0.851 | 1508 | 11313 | 1.14 | 0.004 |
6 | HLA-DRB1 0401 tag | 2.68 | 2.50 to 2.88 | 9.97E-169 | 2378 | 8428 | 1.15 | 1.03 to 1.28 | 9.55E-03 | 991 | 8428 | 2.33 | 6.30E-47 |
6 | HLA-DRB1 SE | 4.08 | 3.64 to 4.56 | 1.18E-131 | 2366 | 1352 | 1.28 | 1.14 to 1.45 | 5.18E-05 | 1315 | 1352 | 3.18 | 2.56E-97 |
6 | PRDM1 | 1.06 | 1.00 to 1.12 | 0.041 | 3827 | 11469 | 1.04 | 0.97 to 1.12 | 0.275 | 1916 | 11469 | 1.02 | 0.692 |
6 | TAGAP | 0.90 | 0.85 to 0.95 | 1.57E-04 | 3824 | 11466 | 0.97 | 0.90 to 1.04 | 0.416 | 1914 | 11466 | 0.92 | 0.068 |
6 | TNFAIP3 locus 1 | 1.29 | 1.21 to 1.37 | 3.70E-16 | 3659 | 12392 | 1.09 | 1.00 to 1.18 | 0.048 | 1862 | 12392 | 1.18 | 3.52E-04 |
6 | TNFAIP3 locus 2 | 0.89 | 0.84 to 0.95 | 2.72E-04 | 3425 | 11923 | 0.93 | 0.85 to 1.02 | 0.109 | 1497 | 11923 | 0.96 | 0.383 |
6 | TNFAIP3 locus 3 | 1.45 | 1.28 to 1.65 | 1.33E-08 | 3414 | 12021 | 0.91 | 0.73 to 1.13 | 0.374 | 1460 | 12021 | 1.60 | 7.36E-05 |
7 | IRF5 | 1.12 | 1.02 to 1.23 | 0.016 | 2739 | 9043 | 1.09 | 0.95 to 1.24 | 0.213 | 1175 | 9043 | 1.03 | 0.696 |
8 | BLK | 1.09 | 1.03 to 1.16 | 3.77E-03 | 3490 | 11481 | 1.15 | 1.05 to 1.25 | 1.53E-03 | 1525 | 11481 | 0.95 | 0.332 |
9 | CCL21 locus 1 | 0.92 | 0.85 to 1.00 | 0.048 | 3199 | 10878 | 1.01 | 0.91 to 1.13 | 0.833 | 1439 | 10878 | 0.91 | 0.145 |
9 | CCL21 locus 2 | 1.13 | 1.07 to 1.20 | 7.68E-06 | 3642 | 11936 | 1.04 | 0.97 to 1.12 | 0.274 | 1855 | 11936 | 1.09 | 0.046 |
9 | TRAF1/C5 | 1.10 | 1.04 to 1.16 | 7.54E-04 | 3135 | 11544 | 1.02 | 0.94 to 1.10 | 0.698 | 1447 | 11544 | 1.08 | 0.073 |
10 | IL2RA locus 1 | 1.14 | 1.06 to 1.23 | 3.21E-04 | 1935 | 5477 | 1.07 | 0.96 to 1.19 | 0.224 | 808 | 5477 | 1.07 | 0.240 |
10 | IL2RA locus 2 | 0.88 | 0.83 to 0.93 | 2.71E-05 | 3806 | 12396 | 0.97 | 0.90 to 1.05 | 0.450 | 1896 | 12396 | 0.91 | 0.033 |
10 | PRKCQ | 0.87 | 0.82 to 0.94 | 1.18E-04 | 3657 | 12427 | 0.95 | 0.86 to 1.04 | 0.281 | 1624 | 12427 | 0.92 | 0.132 |
11 | RAG1/TRAF6 | 0.92 | 0.85 to 0.99 | 0.032 | 3440 | 11379 | 0.98 | 0.88 to 1.09 | 0.723 | 1556 | 11379 | 0.94 | 0.285 |
12 | KIF5A/PIP4K2C | 0.90 | 0.85 to 0.95 | 1.81E-04 | 3688 | 12452 | 0.95 | 0.88 to 1.02 | 0.135 | 1881 | 12452 | 0.95 | 0.237 |
20 | CD40 | 0.89 | 0.84 to 0.95 | 4.36E-04 | 3640 | 11971 | 1.02 | 0.94 to 1.11 | 0.594 | 1858 | 11971 | 0.87 | 0.005 |
22 | IL2RB | 1.15 | 1.08 to 1.21 | 3.15E-06 | 3811 | 12392 | 1.08 | 1.00 to 1.16 | 0.057 | 1900 | 12392 | 1.06 | 0.164 |
N cases, cont: number of cases or controls with available genotype. Comparison ORpos/ORneg: effect size ratio between the OR in CCP-positive and CCP-negative RA, with the p value for its significance. The CI of the effect size OR is not shown to avoid overloading the table