Table 2

Individual study genetic association estimates with patellofemoral (PF) and tibiofemoral (TF) Kellgren-Lawrence (K/L) grade and meta-analysis summary statistics. All results are adjusted for age, sex and body mass index

			PF K/L			TF K/L
Gene	Variant	Cohort	b	SE	p Value	b	SE	p Value
GDF5	rs143383	GOAL	0.024	0.036	0.512	0.042	0.037	0.263
		HCS	0.103	0.055	0.064	0.077	0.058	0.180
		Nottingham	−0.007	0.044	0.876	0.060	0.030	0.049
		Summary	0.033	0.045	0.463	0.058	0.021	0.006
COG5	rs4730250	GOAL	−0.006	0.054	0.908	0.001	0.056	0.988
		HCS	0.175	0.085	0.041	0.108	0.089	0.225
		Nottingham	0.021	0.047	0.657	0.016	0.037	0.655
		Summary	0.030	0.065	0.649	0.020	0.550	0.971
MCF2L	rs11842874	GOAL	0.068	0.075	0.368	0.199	0.078	0.011
		HCS	0.190	0.112	0.091	−0.119	0.117	0.312
		Nottingham	0.084	0.100	0.402	−0.108	0.069	0.121
		Summary	0.099	0.050	0.048	−0.005	0.048	0.920

GOAL, Genetics of Osteoarthritis and Lifestyle study; HCS, Hertfordshire Cohort Study; Nottingham, Nottingham Case-Control Study.