Table 1

 Characteristics of primary publications for biological anti-TNFα agents

ReferenceAnti-TNFα agentTrial nameEnrolment start dateComparatorNPatient population
Elliott et al 199416InfliximabNA1993Placebo72MTX experienced
Moreland et al 199717EtanerceptNAPlacebo180MTX experienced
Maini et al 199818InfliximabNA1994Placebo101MTX experienced
Maini et al 199919InfliximabATTRACT1997Placebo428MTX experienced
Moreland et al 199920EtanerceptNAPlacebo234MTX experienced
Weinblatt et al 199921EtanerceptNAMTX89MTX experienced
Bathon et al 200022EtanerceptERA1997MTX632MTX naive
Kavanaugh et al 200023InfliximabNA1995Placebo28MTX experienced
Choy et al 200224CertolizumabNAPlacebo36MTX experienced
Furst et al 200325AdalimumabSTAR2000Placebo636MTX experienced
van de Putte et al 200326AdalimumabDE0072001Placebo284MTX experienced
Weinblatt et al 200327AdalimumabARMADAMTX271MTX experienced
Keystone et al 200428AdalimumabDE0192002MTX619MTX experienced
van de Putte et al 200429AdalimumabDE0112000Placebo544MTX experienced
Genovese et al 200430EtanerceptNAAnakinra244MTX experienced
Keystone et al 200431EtanerceptNAPlacebo420MTX experienced
Klareskog et al 200432EtanerceptTEMPO2000MTX652MTX experienced
Lan et al 200433EtanerceptNA2000Placebo58MTX experienced
St. Clair et al 200434InfliximabASPIRE2000MTX1004MTX naive
Johnsen et al 200635EtanerceptNA1999Etanercept77MTX experienced
Abe et al 200636InfliximabNA2000Placebo147MTX experienced
Leirisalo-Repo et al 200637InfliximabNEO-RACO2005Placebo99MTX experienced
Westhovens et al 200638InfliximabSTART2001Placebo1082MTX experienced
Zhang et al 200639InfliximabNA2003Placebo173MTX experienced
Breedveld et al 200640AdalimumabPREMIER2001MTX799MTX naive
Kim et al 200741AdalimumabNA2003MTX128MTX experienced
Weisman et al 200742EtanerceptNA2000Placebo535MTX experienced
Zhou et al 200743GolimumabNA2001Placebo36MTX experienced
Durez et al 200744InfliximabNA2003MTX and prednisone44MTX naive
Fleischmann et al 200845*CertolizumabFAST4WARD2003Placebo220MTX experienced
Keystone et al 200846CertolizumabRAPID12005MTX982MTX experienced
Smolen et al 200847*CertolizumabRAPID22005MTX619MTX experienced
Combe et al 200848*Etanercept3092000SSZ254MTX experienced
Emery et al 200849EtanerceptCOMET2004MTX542MTX naive
Kameda et al 200850EtanerceptJESMR2005MTX151MTX experienced
Sheehy et al 200851EtanerceptNAMTX40MTX naive
Wyeth data on fileEtanercept0881A1-3192006MTX156MTX experienced
Sennels et al 200852EtanerceptADORE2003Etanercept25MTX experienced
Weinblatt et al 200853EtanerceptNA2005Etanercept200MTX experienced
Miyasaka et al 200854AdalimumabCHANGE2004Placebo352MTX experienced
Kay et al 200855GolimumabNA2003MTX172MTX experienced
Keystone 200814GolimumabGO–FORWARD2005MTX444MTX experienced
Emery et al 200915GolimumabGO–BEFORE2005MTX634MTX naive
Smolen et al 200956GolimumabGO–AFTER2006Placebo461MTX experienced
  • MTX, methotrexate; NA, not available; TNF, tumour necrosis factor.

  • * Date denotes the first date of publication (online)