Canonical pathway | Type of pathway | p Value | Genes in pathway |
---|---|---|---|
SLE/RA overlap | |||
Dendritic cell maturation | Cellular immune response, cytokine signalling, pathogen-influenced signalling | 1.4×10−4 | STAT4, FCGR2A, HLA-DRB1 |
T helper cell differentiation | Cellular immune response, cytokine signalling | 9.8×10−4 | STAT4, HLA-DRB1 |
CTLA4 signalling in cytotoxic T lymphocytes | Cellular immune response | 1.8×10−3 | HLA-DRB1, PTPN22 |
Role of NFAT in regulation of the immune response | Cellular immune response, humoral immune response, intracellular and second messenger signalling | 6.2×10−3 | FCGR2A, HLA-DRB1 |
TNFR2 signalling | Apoptosis, cytokine signalling | 0.02 | TNFAIP3 |
B-cell development | Cellular growth, proliferation and development, humoral immune response | 0.02 | HLA-DRB1 |
Antigen presentation pathway | Cellular immune response, humoral immune response | 0.03 | HLA-DRB1 |
Allograft rejection signalling | Cellular immune response, disease specific pathway | 0.03 | HLA-DRB1 |
Autoimmune thyroid disease signalling | Cellular immune response, disease specific pathway, humoral immune response | 0.03 | HLA-DRB1 |
Graft-versus-host disease signalling | Cellular immune response, disease specific pathway | 0.03 | HLA-DRB1 |
TNFR1 signalling | Apoptosis, cytokine signalling | 0.03 | TNFAIP3 |
Nur77 signalling in T lymphocytes | Apoptosis, cellular immune response, Nuclear receptor signalling | 0.04 | HLA-DRB1 |
Calcium-induced T lymphocyte apoptosis | Apoptosis, cellular immune response | 0.04 | HLA-DRB1 |
CD40 signalling | Cellular immune response, humoral immune response | 0.04 | TNFAIP3 |
IL-10 signalling | Cellular immune response, cytokine signalling | 0.04 | FCGR2A |
JAK/Stat signalling | Apoptosis, cellular growth, proliferation and development, intracellular and second messenger signalling | 0.04 | STAT4 |
RA only | |||
iCOS-iCOSL signalling in T helper cells | Cellular immune response | 9.8×10−9 | PTPRC, CD28, PRKCQ, CD40, IL2RA, IL2RB |
T helper cell differentiation | Cellular immune response, cytokine signalling | 5.2×10−8 | IL21, IL6ST, CD28, CD40, IL2RA |
Altered T-cell and B-cell signalling in RA | Cellular immune response, disease-specific pathways | 6.6×10−6 | IL21, CD28, CD40, CCL21 |
T-cell receptor signalling | Cellular immune response | 1.3×10−5 | PTPRC, CD28, PRKCQ, CTLA4 |
IL-12 signalling and production in macrophages | Cellular immune response, cytokine signalling | 2.0×10−5 | TRAF6, PRKCQ, CD40, REL |
CD28 signalling in T helper cells | Cellular immune response | 2.7×10−5 | PTPRC, CD28, PRKCQ, CTLA4 |
CD40 signalling | Cellular immune response, humoral immune response | 1.0×10−4 | TRAF6, CD40, TRAF1 |
Cross-talk between dendritic cells and natural killer cells | Cellular immune response | 3.7×10−4 | CD28, CD40, IL2RB |
B cell development | Cellular growth, proliferation and development, humoral immune response | 9.3×10−4 | PTPRC, CD40 |
Systemic lupus erythematosus signalling | Disease-specific pathways | 1.0×10−3 | PTPRC, CD28, CD40 |
Role of macrophages, fibroblasts and endothelial cells in rheumatoid arthritis | Disease-specific pathways | 1.2×10−3 | TRAF6, IL6ST, PRKCQ, TRAF1 |
NF-κB signalling | Cellular immune response, cytokine signalling, humoral immune response, organismal growth and development | 1.3×10−3 | TRAF6, PRKCQ, CD40 |
April -mediated signalling | Apoptosis | 1.5×10−3 | TRAF6, TRAF1 |
Dendritic cell maturation | Cellular immune response, cytokine signalling, pathogen-influenced signalling | 1.6×10−3 | TRAF6, CD40, CD58 |
B-cell activating factor signalling | Cellular growth, proliferation and development, humoral immune response | 1.7×10−3 | TRAF6, TRAF1 |
Allograft rejection signalling | Cellular immune response, disease-specific pathways | 1.8×10−3 | CD28, CD40 |
Autoimmune thyroid disease signalling | Cellular immune response, disease-specific pathways, humoral immune response | 1.9×10−3 | CD28, CD40 |
Primary immunodeficiency signalling | Cellular immune response, disease-specific pathways, humoral immune response | 2.3×10−3 | PTPRC, CD40 |
IL-2 signalling | Cellular immune response, cytokine signalling | 3.1×10−3 | IL2RA, IL2RB |
Lymphotoxin β receptor signalling | Apoptosis | 3.2×10−3 | TRAF6, TRAF1 |
Activation of IRF by cytosolic pattern recognition receptors | Cellular immune response | 4.1×10−3 | TRAF6, CD40 |
Small cell lung cancer signalling | Cancer, disease-specific pathways | 5.5×10−3 | TRAF6, TRAF1 |
Communication between innate and adaptive immune cells | Cellular immune response | 5.8×10−3 | CD28, CD40 |
IL-6 signalling | Cellular immune response, cytokine signalling | 8.1×10−3 | TRAF6, IL6ST |
CTLA4 aignalling in cytotoxic T lymphocytes | Cellular immune response | 8.7×10−3 | CD28, CTLA4 |
Type I diabetes mellitus signalling | Apoptosis, disease-specific pathways, | 0.01 | TRAF6, CD28 |
PKC signalling in T lymphocytes | Cellular immune response | 0.01 | CD28, PRKCQ |
Hepatic fibrosis/hepatic stellate cell activation | Disease-specific pathways | 0.02 | CD40, CCL21 |
Hepatic cholestasis | Disease-specific pathways | 0.02 | TRAF6, PRKCQ |
B cell receptor signalling | Humoral immune response | 0.02 | PTPRC, PRKCQ |
IL-8 signalling | Cellular immune response, cytokine signalling | 0.03 | TRAF6, PRKCQ |
Acute phase response signalling | Cytokine signalling | 0.03 | TRAF6, IL6ST |
Role of NFAT in regulation of the immune response | Cellular immune response, humoral immune response, intracellular and second messenger signalling | 0.03 | CD28, PRKCQ |
Role of NFAT in cardiac hypertrophy | Cardiovascular signalling, disease-specific pathways | 0.03 | IL6ST, PRKCQ |
TNFR2 signalling | Apoptosis, cytokine signalling | 0.04 | TRAF1 |
4-1BB signalling in T lymphocytes | Cellular immune response | 0.04 | TRAF1 |
SLE only | |||
Mitotic roles of polo-like kinase | Cell cycle regulation | 0.035 | PTTG1 |
Angiopoietin signalling | Cardiovascular signalling, cellular growth, proliferation and development, growth factor signalling | 0.041 | TNIP1 |
Ubiquinone biosynthesis | Metabolism of cofactors and vitamins | 0.045 | UHRF1BP1 |
Caveolar-mediated endocytosis signalling | Cellular immune response, organismal growth and development, pathogen-influenced signalling | 0.046 | ITGAM |
NFAT, nuclear factor of activated T cells; RA, rheumatoid arthritis; SLE, systemic lupus erythematosus.