Kaplan–Meier estimates of patients without subsequent new DUs at week 20 by number of DUs at baseline
| <4 DUs at baseline | ≥4 DUs at baseline | |||
|---|---|---|---|---|
| Event-free rate (%) | Placebo (n=61) | Bosentan (n=61) | Placebo (n=29) | Bosentan (n=37) |
| First new DU | 45.8 | 47.7 | 24.1 | 23.4 |
| Second new DU | 66.5 | 70.1 | 44.8 | 57.3 |
| Third new DU | 84.2 | 85.0 | 55.2 | 75.3 |
| Fourth new DU | 84.0 | 96.1 | 58.6 | 84.2 |
| Fifth new DU | 92.9 | 98.0 | 72.4 | 90.6 |
DU, digital ulcer.