Table 3

Meta-analysis of previously published allele frequency data together with data from our study—AutoCure

		Before AutoCure meta-analysis						Meta-analysis all data
SNP	Gene	MAF case	MAF control	Case/control	Het p	χ² p	OR (95% CI)	MAF case	MAF control	Case/control	Het p	χ² p	OR (95% CI)
rs231775	CTLA4	0.40	0.38	3888/3367	0.862	0.003	1.11 (1.04 to 1.18)	0.39	0.38	6160/6684	0.098	0.009	1.07 (1.02 to 1.13)
rs743777	IL2RB	0.33	0.31	7970/7277	0.039	1.77e-07	1.33 (1.19 to 1.48)	0.33	0.31	11038/10665	0.003	1.44e-06	1.25 (1.14 to 1.37)
rs763361	CD226	0.48	0.46	7102/7093	0.836	0.01	1.06 (1.02 to 1.12)	0.48	0.47	10254/10427	0.949	0.009	1.06 (1.01 to 1.10)
rs1160542	AFF3	0.48	0.45	7756/7755	0.47	6.73e-07	1.12 (1.07 to 1.18)	0.48	0.46	10902/11158	0.810	1.15e-07	1.11 (1.07 to 1.16)
rs1678542	KIF5A	0.35	0.37	11234/14083	0.576	1.70e-08	0.90 (0.87 to 0.93)	0.35	0.37	14378/17490	0.357	3.64e-09	0.90 (0.87 to 0.94)
rs2104286	IL2RA	0.26	0.28	6963/7043	0.034	3.74e-05	0.89 (0.85 to 0.94)	0.25	0.27	10112/10450	0.190	2.48e-05	0.91 (0.86 to 0.95)
rs2476601	PTPN22	0.15	0.10	17285/17353	0.004	7.30e-92	1.61 (1.54 to 1.69)	0.15	0.10	20079/20673	0.0003	2.30e-98	1.60 (1.53 to 1.67)
rs2812378	CCL21	0.36	0.34	11000/13570	0.658	3.85e-07	1.10 (1.06 to 1.15)	0.36	0.34	14146/16975	0.357	7.79e-07	1.09 (1.05 to 1.13)
rs2900180	TRAF1/C5	0.38	0.34	9210/10281	2.05e-06	1.08e-12	1.17 (1.12 to 1.22)	0.38	0.34	12357/13621	1.69e-06	6.50e-13	1.15 (1.11 to 1.19)
rs3087243	CTLA4	0.42	0.45	9314/9866	0.362	2.06e-07	0.90 (0.86 to 0.93)	0.42	0.45	12372/13267	0.326	4.08e-08	0.90 (0.87 to 0.94)
rs4750316	PRKCQ	0.18	0.20	11231/14094	0.717	2.40e-08	0.88 (0.84 to 0.92)	0.18	0.19	14306/17482	0.471	1.54e-07	0.90 (0.86 to 0.93)
rs4810485	CD40	0.23	0.25	10988/13629	0.304	4.70e-10	0.87 (0.84 to 0.91)	0.23	0.25	14031/17016	0.045	6.07e-10	0.89 (0.85 to 0.92)
rs5029937	6q23	0.05	0.04	5469/6024	0.231	6.84e-08	1.43 (1.30 to 1.63)	0.05	0.03	7731/9403	0.256	4.62e-10	1.42 (1.27 to 1.59)
rs6822844	IL2/IL21	0.16	0.19	9810/10031	0.505	5.70e-10	0.85 (0.80 to 0.89)	0.16	0.18	12953/13370	0.085	5.89e-08	0.88 (0.84 to 0.92)
rs6920220	6q23	0.23	0.20	11420/11008	0.383	5.90e-16	1.21 (1.15 to 1.26)	0.23	0.20	14566/14415	0.316	1.08e-15	1.18 (1.14 to 1.23)
rs7574865	STAT4	0.25	0.22	11331/12814	0.462	2.76e-16	1.20 (1.15 to 1.25)	0.25	0.22	14394/16131	0.307	2.99e-15	1.18 (1.14 to 1.23)
rs10760130	TRAF1/C5	0.47	0.42	7381/9927	5.86e-06	8.84e-12	1.16 (1.12 to 1.22)	0.46	0.43	10536/13269	9.62e-06	6.03e-12	1.15 (1.10 to 1.19)
rs13207033	6q23	0.24	0.27	10301/10436	0.092	1.40e-07	0.89 (0.85 to 0.93)	0.24	0.27	13285/13818	0.039	2.52e-07	0.90 (0.86 to 0.94)

χ² p, χ² p value; Het p, heterogeneity χ² p value; SNP, single-nucleotide polymorphism.