Synovial fluid inflammatory mediators relative to carriage of interleukin 1 receptor antagonist (IL1RN) haplotypes
| Synovial fluid analyte | IL1RN haplotype (rs419598/rs315952/rs9005=CTA) | N* | Mean† | SD | p Value‡ |
|---|---|---|---|---|---|
| CRP (ng/ml) | 0 | 28 | 5195.3 | 4991.4 | 0.74 |
| 1 or 2 copies | 21 | 5160.4 | 4045.8 | ||
| IL6 (pg/ml) | 0 | 28 | 687.1 | 633.5 | 0.38 |
| 1 or 2 copies | 19 | 430.2 | 437.4 | ||
| IL10§ (pg/ml) | 0 | 28 | 109.4 | 222.7 | 0.034 |
| 1 or 2 copies | 19 | 13.4 | 42.7 | ||
| IL1β§ (pg/ml) | 0 | 28 | 3.46 | 8.38 | 0.40 |
| 1 or 2 copies | 19 | 0.63 | 2.04 | ||
| IL1Ra¶ (pg/ml) | 0 | 16 | 483 | 334.6 | 0.72 |
| 1 or 2 copies | 7 | 468.5 | 184.2 | ||
| MCP (pg/ml) | 0 | 29 | 763.7 | 389 | 0.49 |
| 1 or 2 copies | 21 | 789.7 | 303.3 | ||
| MIP (pg/ml) | 0 | 29 | 380.9 | 233.4 | 0.91 |
| 1 or 2 copies | 21 | 360.6 | 169.1 | ||
| COMP (ng/ml) | 0 | 29 | 35020 | 23280 | 0.52 |
| 1 or 2 copies | 21 | 30441 | 20677 |
↵* Number of patients.
↵† The mean of the mediator values of the two knees was used to represent the mediator value for the patient.
‡ Non-parametric Wilcoxon test.
↵§ Values of these parameters that were below the lower limit of detection of the assay were assigned the value of 0.5 times the lower limit to facilitate data analysis. Fifty-two per cent of the IL10 values and 82% of the IL1β values were below the detection threshold limit.
↵¶ aIL1Ra analysis was performed at a later time than analysis of the other analytes and fewer samples remained available with sufficient volume for analysis.
COMP, cartilage oligomeric matrix protein; IL1, interleukin 1; IL1Ra, interleukin 1 receptor antagonist; MCP, monocyte chemotactic protein-1; MIP, macrophage inflammatory protein-1β.