Number and percentage of significantly differentially methylated IFN-regulated genes found in B lymphocytes from patients with pSS who were autoantibody positive or negative compared with the control cohort, respectively
| Patients subgroups compared with controls | Differentially methylated genes used for analysis | Differentially methylated IRGs found | Percentage of differentially methylated IRGs found |
|---|---|---|---|
| Anti SSA+ anti-SSB+ | 699 genes | 76 genes | 10.9 |
| Anti SSA+ anti-SSB− | 242 genes | 24 genes | 9.9 |
| Anti-SSA− | 47 genes | 2 genes | 4.3 |
Genes with at least two CpG sites significantly differentially methylated (at least 7% median difference of methylation, p<0.01) were included in the analysis.
IFN, interferon; IRGs, IFN-regulated genes; pSS, primary Sjögren's syndrome.