| Celecoxib 200 mg/d | Celecoxib 400 mg/d | Diclofenac 100 mg/d | |
|---|---|---|---|
| Laboratory value elevation | n = 2988 | n = 2948 | n = 2998 |
| AST >/= 3x ULN at final visit | 1 (<0.1%) | 3 (0.1%) | 20 (0.7%)* |
| ALT >/= 3x ULN at final visit | 6 (0.2%) | 6 (0.2%) | 45 (1.5%)* |
| Adverse events, incidence | |||
| AST increased from pretreatment | 11 (0.3%) | 13 (0.4%) | 31 (0.9%)** |
| ALT increased from pretreatment | 20 (0.6%) | 15 (0.4%) | 58 (1.7%)* |
ULN: upper limit of normal; diclofenac vs celecoxib 200 or 400 mg/d:
↵* p < 0.01.