Recommendation 3: summary of studies on the use of MRI in monitoring disease activity in axial spondyloarthritis
| Correlation | ||||||||
|---|---|---|---|---|---|---|---|---|
| Studies | No. | Region | MRI scoring method | ASDAS | BASDAI | CRP | ESR | Pain |
| Longitudinal/RCT | ||||||||
| Marzo-Ortega et al20 | 76 | Spine | LEEDS | – | NS | NS | – | NS |
| Oostveen et al21 | 25 | SIJ | mNY | OR 2.1 | OR 2.1 | OR 1.2 | ||
| Baraliakos et al50 | 40 | Spine | ASspiMRI-a | – | NS | NS | NS | – |
| Bonel et al52 | 28 | Spine | ASspiMRI-a | – | 0.41 | – | – | – |
| Braun et al53 | 20 | Spine | ASspiMRI-a/c | – | 0.49–0.6 | – | – | – |
| Braun et al54 | 98 | Spine | ASspiMRI-a | 0.35 | NS | 0.4 | – | NS |
| Lambert 200761 | 82 | Spine/SIJ | SPARCC | – | NS | p=0.018 | – | NS |
| Machado et al63 | 221 | Spine | ASspiMRI-a | 0.14 | NS | – | – | – |
| Machado et al64 | 221 | Spine | ASspiMRI-a | 0.23 | NS | 0.32 | – | – |
| Maksymowych et al66 | 68 | Spine | SPARCC | – | NS | 0.65–0.68 | – | NS |
| Maksymowych et al67 | 36 | Spine | SPARCC | – | NS | 0.45 | 0.44 | – |
| Marzo-Ortega et al68 | 42 | Spine/SIJ | LEEDS | – | p=0.04 | – | – | – |
| Pedersen et al69 | 82 | Spine/SIJ | Berlin | 0.46/0.31 | −0.41/−0.31 | NS | – | – |
| Puhakka et al71 | 34 | SIJ | BME | – | NS | – | – | – |
| Rudwaleit et al73 | 62 | Spine/SIJ | Berlin | – | NS | NS | NS | NS |
| Sieper et al74 | 20 | Spine | ASspiMRI-a | – | 0.5 | NS | NS | – |
| Song et al76 | 76 | Spine/SIJ | ASspiMRI-a/Berlin | p=0.04 | – | NS | – | – |
| Visvanathan et al77 | 279 | Spine | ASspiMRI-a | – | – | p<0.001 | – | – |
| Cross-sectional/case-control | ||||||||
| Blachier 201351 | 648 | Spine/SIJ | Dichotomous | – | – | – | – | aOR 1.71–2.86 |
| Goh et al55 | 34 | Spine | ASspiMRI-a | – | NS | NS | NS | – |
| Kiltz et al59 | 100 | Spine/SIJ | Berlin | NS | NS | 0.22 | – | – |
| Konca et al60 | 50 | Spine | ASspiMRI-a | 0.37 | NS | 0.33 | 0.39 | – |
| Puhakka et al70 | 41 | SIJ | BME enhancement | – | NS | – | – | – |
| Weber et al79 | 197 | ACW | Dichotomous | – | – | – | – | κ 0.21–0.33 |
The Spearman test for rank correlation is used for test of correlation, values are correlation coefficients (rho), if not otherwise indicated. p Values indicate the level of statistical significance.
aOR, adjusted odd ratio; ACW, anterior chest wall; AS, ankylosing spondylitis; ASDAS, Ankylosing Spondylitis Disease Activity Score; ASspiMRI-a/c, ankylosing spondylitis spine MRI score for activity; BASDAI, Bath Ankylosing Spondylitis Disease Activity Score; BME, bone marrow oedema; CRP, C-reactive protein; ESR, erythrocyte sedimentation rate; LEEDS, Leeds MRI scoring system; mNY, modified New York; MRI, magnetic resonance imaging; No., number of individuals included in the study; NS, not statistically significant; OR, odds ratio; RCT, randomised controlled trial; SIJ, sacroiliac joints; SPARCC, Spondyloarthritis Research Consortium of Canada Scoring System; –, not done.