Table 1.

Modification of TNFi or DMARDs according to different TNFi drugs

	Etanercept	Adalimumab	Infliximab	p

Modification 1	1.4	0	20	<0.001^^,^*
Modification 2	10.4	11.2	25	0.001^, 0.024^*
Modification 3	14.5	12.5	13.7	>0.05
Modification 4	15.3	11.3	16.3	>0.05
Modification Total	30.2	26.3	45.0	0.017^, 0.013^*

Mod 1: Change TNFi duration or dosage; Mod 2: Change of TNFi due to inefficacy or lost of efficacy; Mod 3: Dosage increase at DMARDs or steroid; Mod 4: Add to DMARDs or steroid.
↵* ETA vs. INF
↵** ADA vs. INF.