Case 1 | Case 2 | Case 3 | Case 4 | Case 5 | Case 6 | Case 7 | |
---|---|---|---|---|---|---|---|
Sex | F | F | F | M | M | F | F |
Age (years) | 42 | 78 | 34 | 58 | 48 | 30 | 57 |
Underlying disease | RA | RA | RA | SA | SA | Uveitis | RA |
Anti-TNF drug | IFX | IFX | IFX | IFX | GLM | ADA | IFX |
Cumulative dose (mg) | 4200 | 3360 | 630 | 8420 | 50 | 6040 | 17810 |
Neurological complication | DMPN | Unilateral PDON | DMPN anti-GAD | SMS anti-GAD | Bilateral PDON | Bilateral PDON | Unilateral PDON |
Discontinue anti-TNF | Yes | Yes | Yes | Yes | Yes | Yes | Yes |
Additional treatment | IVIG | GC | IVIG + GC | Botulinum toxin | None | None | None |
Outcome | Recovered | Recovered | Recovered | Partially recovered | Follow up | Recovered | Recovered |
F: female; M: male; IVIg: intravenous immunoglobulin; GC: glucocorticoids.