| No-flare | Flare | p-value | |
|---|---|---|---|
| Number of patients (%) | 140 (57) | 108 (43) | |
| Age in years, mean (SD) | 58 (11) | 62 (9) | 0.005 |
| Disease duration in years, median (IQ-range) | 8 [4-13] | 12.5 [6-19] | 0.002 |
| Female (%) | 66 | 66 | 0.5 |
| IgM RF positive (%) | 64 | 80 | 0.020 |
| Anti-CCP positive (%) | 63 | 75 | 0.062 |
| Erosive (%) | 59 | 64 | 0.5 |
| DAS28, mean (SD) | 2.13 (1.0) | 2.16 (0.70) | 0.8 |
| US signs of arthritis ≥1 joint (%) | 56 | 72 | 0.011 |