Comparison of outcomes with ETN vs ADA and ETN vs CZP using MAIC and STC methods
| Assessment | Observed change | Method | Predicted change with ETN* (95% CI) | Treatment effect* | |
|---|---|---|---|---|---|
| ETN | ADA | ||||
| BASDAI | −3.0 | −1.9 | MAIC | −2.6 (−3.4, −1.7) | −0.7 (−1.4, 0.1) |
| STC | −2.4 (−3.7, −1.1) | −0.5 (−1.9, 0.9) | |||
| BASFI | −2.4 | −1.1 | MAIC | −1.5 (−2.3, −0.7) | −0.4 (−1.1, 0.3) |
| STC | −1.7 (−3.0, −0.4) | −0.6 (−2.0, 0.8) | |||
| Assessment | Observed change | Method | Predicted change with ETN* (95% CI) | Treatment effect* | |
| ETN | CZP | ||||
| BASDAI | −3.0 | −2.8 | MAIC | −2.8 (−3.5, −2.1) | 0.0 (−0.8, 0.8) |
| STC | −2.6 (−4.0, −2.4) | 0.2 (−1.1, 1.5) | |||
| BASFI | −2.4 | −2.0 | MAIC | −1.8 (−2.5, −1.1) | 0.2 (−0.6, 0.9) |
| STC | −1.8 (−3.0, −1.5) | 0.2 (−1.1, 1.5) | |||
↵* Changes from baseline to week 12; results adjusted for differences in populations and study effect.