Cytokine mRNA expression in 58 patients with GPA, n (%)
| mRNA | Healthy volunteers (n=40) | Generalized GPA (n=33) | Localized GPA (n=25) |
|---|---|---|---|
| IFN-α | 1 (2.5) | 12 (36.4)** | 11 (44.0)** |
| IFN-γ | 12 (30.0) | 8 (24.2) | 2 (8.0)* |
| IL-1β | 14 (35.0) | 16 (48.5) | 11 (44.0) |
| IL-2 | 0 | 6 (18.2)* | 2 (8.0) |
| IL-4 | 0 | 2 (6.1) | 1 (4.0) |
| IL-6 | 8 (20.0) | 12 (36.4) | 5 (20.0) |
| IL-8 | 4 (10.0) | 13 (39.4)* | 12 (48.0) |
| IL-10 | 8 (20.0) | 7 (21.2) | 7 (28.0) |
| IL-12 | 28 (70.0) | 1 (3.0)** | 2 (8.0)** |
| IL-18 | 12 (30.0) | 17 (51.5) | 13 (52.0) |
| TNF-α | 30 (75.0) | 12 (36.4)** | 5 (20.0)** |