Variable | Trial characteristics | ||
---|---|---|---|
Trials | OR (95% CI) | p-interaction | |
Overall | 62 | 3.96 (3.41 to 4.60) | N.A. |
Medication history | 0.0002 | ||
DMARD-naïve | 8 | 1.97 (1.39 to 2.79) | |
DMARD-inadequate responders | 49 | 4.34 (3.75 to 5.01) | |
Bio-inadequate responders | 5 | 3.92 (2.58 to 5.97) | |
Variable | Participant characteristics | ||
Trials | Coefficient (95% CI) | p-value | |
Baseline disease duration (years) | 62 | 1.05 (1.00 to 1.11) | 0.03 |