| % | DAS28(CRP) remission (<2.6) | SDAI remission (≤3.3) |
|---|
| | |
|---|
| PREMIER Wk 26 | DE019 Wk 24 | PREMIER Wk 26 | DE019 Wk 24 |
|---|
| | | | |
|---|
| ADA+MTX (n=98) | PBO+MTX (n=48) | ADA+MTX (n=46) | PBO+MTX (n=9) | ADA+MTX (n=62) | PBO+MTX (n=31) | ADA+MTX (n=21) | PBO+MTX (n=4) |
|---|
|
|---|
| CDC Wk 52 | 51.0* | 47.9* | 39.1* | 33.3* | 58.1** | 54.8** | 42.9** | 50.0** |
| DAS28(CRP)<2.6 Wk 52 | 85.7 | 66.7 | 71.7 | 55.6 | 90.3 | 77.4 | 81.0 | 75.0 |
| ΔmTSS≤0.5 Wk 24/26–52 | 77.6 | 78.7 | 79.5 | 55.6 | 77.4 | 83.9 | 89.5 | 75.0 |
| HAQ-DI<0.5 Wk 52 | 76.5 | 79.2 | 65.2 | 66.7 | 80.6 | 83.9 | 71.4 | 75.0 |
| ΔmTSS (mean) Wk 24/26 | 0.27 | 0.46 | 0.393 | 1.0 | 0.40 | 0.04 | 0.68 | 1.875 |
| ΔmTSS ≥1.5 Wk 24/26–52 | 14.3 | 17.0 | 13.6 | 22.2 | 12.9 | 12.9 | 10.5 | 25.0 |