Table 3

Subhazard ratios (95% CI) using the competing risk model for each non-GCA/GCA cohort (imputed data)

Non-GCA (n=41 994)GCA (n=6999)
FactorUnivariateMultivariateUnivariateMultivariate
Age (years)1.03 (1.02 to 1.04)***1.00 (0.99 to 1.02)0.99 (0.98 to 1.00)+0.97 (0.94 to 1.00)
BMI (kg/m2)0.99 (0.97 to 1.02)1.00 (0.97 to 1.03)0.99 (0.95 to 1.03)1.00 (0.96 to 1.04)
Male gender3.95 (3.11 to 5.01)***3.49 (2.70 to 4.52)***2.36 (1.59 to 3.49)***2.10 (1.38 to 3.19)**
Ex-smoker3.02 (2.24 to 4.08)***2.08 (1.52 to 2.85)***2.58 (1.49 to 4.47)**2.20 (1.22 to 3.98)**
Current smoker3.02 (2.21 to 4.13)***3.00 (2.17 to 4.14)***4.24 (2.50 to 7.16)***3.79 (2.20 to 6.53)***
Previous alcohol1.66 (0.90 to 3.03)+1.16 (0.63 to 2.14)0.68 (0.20 to 2.34)0.62 (0.19 to 1.99)
Current alcohol1.28 (0.85 to 1.92)0.94 (0.62 to 1.43)1.26 (0.72 to 2.21)0.91 (0.52 to 1.60)
Prior HLD1.88 (1.14 to 3.11)*1.37 (0.80 to 2.34)1.04 (0.38 to 2.82)1.19 (0.40 to 3.53)
Prior HLD treatment1.97 (1.44 to 2.71)***1.21 (0.83 to 1.76)0.77 (0.37 to 1.60)0.69 (0.31 to 1.50)
Prior HT1.16 (0.89 to 1.51)0.92 (0.68 to 1.24)0.91 (0.57 to 1.43)0.93 (0.55 to 1.58)
Prior HT treatment1.72 (1.36 to 2.16)***1.42 (1.06 to 1.89)*1.23 (0.83 to 1.83)1.62 (1.00 to 2.61)*
Prior DM0.54 (0.30 to 0.97)*0.32 (0.18 to 0.58)***0.22 (0.05 to 0.88)*0.19 (0.05 to 0.77)*
Prior CVD2.83 (2.10 to 3.81)***1.65 (1.20 to 2.29)**1.38 (0.77 to 2.47)1.28 (0.72 to 2.29)
Prior CBVD1.36 (0.88 to 2.09)+0.88 (0.56 to 1.38)0.82 (0.38 to 1.77)0.79 (0.36 to 1.73)
Prior PVD2.93 (1.68 to 5.13)***1.84 (1.04 to 3.25)*0.70 (0.17 to 2.86)0.68 (0.17 to 2.72)

  • *p<0.05.

  • **p<0.01.

  • ***p<0.001.

  • BMI, body mass index; CBVD, cerebrovascular disease; CVD, cardiovascular disease; DM, diabetes mellitus; GCA, giant cell arteritis; HLD, hyperlipidaemia; HT, hypertension; PVD, peripheral vascular disease.