Logistic regression results after splitting the wGRSfull_G into quintiles (6370 anti-CCP-positive cases and 15 489 healthy controls)
| Group | OR | p Value | 95% CI | |
|---|---|---|---|---|
| Compare each group to the lowest risk group (1st quintile) | ||||
| Quintile 1 | Reference group (lowest risk group) | 1 | NA | NA |
| Quintile 2 | 2.25 | <0.00001 | 1.94 to 2.61 | |
| Quintile 3 | Median-risk group | 4.25 | <0.00001 | 3.70 to 4.88 |
| Quintile 4 | 8.78 | <0.00001 | 7.67 to 10.04 | |
| Quintile 5 | High-risk group | 27.13 | <0.00001 | 23.70 to 31.05 |
| Validation | ||||
| Quintile 5 | High-risk group | 18.00 | <0.00001 | 13.67 to 23.71 |
| Compare each quintile to the median-risk group (3rd quintile) | ||||
| Quintile 1 | Lowest risk group | 0.24 | <0.00001 | 0.20 to 0.27 |
| Quintile 2 | 0.53 | <0.00001 | 0.47 to 0.59 | |
| Quintile 3 | Reference group (median-risk group) | 1 | NA | NA |
| Quintile 4 | 2.07 | <0.00001 | 1.88 to 2.27 | |
| Quintile 5 | High-risk group | 6.38 | <0.00001 | 5.80 to 7.02 |
| Validation | ||||
| Quintile 5 | High-risk group | 4.92 | <0.00001 | 3.87 to 6.26 |
CCP, cyclic citrullinated peptide; wGRSfull_G, wGRS including all 45 susceptibility SNPs, five HLA amino acids and gender.