Subhazard ratios (95% CI) of non-GCA/GCA groups using the competing risk model (imputed data)
| Analysis | Risk of AA | Risk ratio | Univariate model (SHR (95% CI)) | Multivariate model† (SHR (95% CI)) |
|---|---|---|---|---|
| Primary analysis | ||||
| Non-GCA | 0.68% (284/41 994) | – | Reference | Reference |
| GCA | 1.43% (100/6999) | 2.1 | 2.11 (1.68 to 2.65)*** | 1.92 (1.52 to 2.41)*** |
| Sensitivity analysis 1 | ||||
| Non-GCA | 0.93% (391/41 994) | – | Reference | Reference |
| GCA | 1.73% (121/6999) | 1.9 | 1.86 (1.51 to 2.28)*** | 1.68 (1.36 to 2.06)*** |
| Sensitivity analysis 2 | ||||
| Non-GCA | 0.70% (292/41 994) | – | Reference | Reference |
| GCA | 1.49% (104/6999) | 2.1 | 2.14 (1.71 to 2.67)*** | 1.94 (1.55 to 2.43)*** |
Primary analysis: AA outcome comprises definite events in the GPRD. Sensitivity analysis 1: AA outcome comprises definite events in the GPRD or the HES database. Sensitivity analysis 2: AA outcome comprises definite or possible events in the GPRD.
***p<0.001.
†Adjusted for BMI, smoking, alcohol, hyperlipidaemia, lipid-lowering medication, hypertension, antihypertensive drugs, diabetes, cardiovascular disease, cerebrovascular disease, peripheral vascular disease.
AA, aortic aneurysm; BMI, body mass index; GCA, giant cell arteritis; GPRD, General Practice Research Database; HES, Hospital Episode Statistics; SHR, subhazard ratio.