Meta-analysis summary statistics for the association of allele G at rs8044769 with hip or knee OA
| OA site | Covariates | N cases/controls | *F.E. OR (95% CIs) | F.E. p value | †R.E. OR (95% CIs) | R.E. p value | ‡q p value | §I2 | ¶Power |
|---|---|---|---|---|---|---|---|---|---|
| Hip | Sex | 4355/4967 | 1.04 (0.98 to 1.11) | 0.170 | 1.04 (0.97 to 1.12) | 0.287 | 0.328 | 0.13 | 0.90 |
| Hip | Sex, BMI | 4355/4967 | 1.00 (0.94 to 1.08) | 0.936 | 0.98 (0.90 to 1.08) | 0.749 | 0.166 | 0.36 | 0.90 |
| Hip | Sex, BMI, age | 4258/4788 | 1.00 (0.94 to 1.08) | 0.97 | 1.00 (0.93 to 1.08) | 0.929 | 0.312 | 0.16 | 0.89 |
| Knee | Sex | 5409/5362 | 1.08 (1.02 to 1.14) | 0.009 | 1.08 (1.00 to 1.16) | 0.056 | 0.138 | 0.38 | 0.94 |
| Knee | Sex, BMI | 5409/5362 | 0.99 (0.93 to 1.05) | 0.666 | 0.99 (0.93 to 1.05) | 0.704 | 0.338 | 0.12 | 0.94 |
| Knee | Sex, BMI, age | 5228/5183 | 0.96 (0.90 to 1.03) | 0.298 | 0.97 (0.90 to 1.05) | 0.484 | 0.227 | 0.26 | 0.93 |
*F.E. Fixed effects.
†R.E. Random effects.
‡q_p value Cochran's heterogeneity statistic's p value.
§I2 Heterogeneity index.
¶Power has been calculated for α=0.05, risk allele frequency=0.5 and effect size=1.1, as estimated in the arcOGEN replication only GWAS.11