Risk of serious infection by type and site (*no events)
| Events | RA vs. NIRD | RA only – DMARD treatment category | |||
|---|---|---|---|---|---|
| HR (95% CI) | TNF | nTNF | MTX | ||
| All | 2496 | 1.20 (1.04, 1.39) | 1.1 (0.9, 1.2) | 1.2 (0.8, 1.9) | 0.8 (0.7, 0.9) |
| Opportunistic | 62 | 2.03 (0.78, 5.26) | 1.1 (0.5, 2.4) | 1.9 (0.3, 14.3) | 1.0 (0.6, 1.8) |
| By type: | |||||
| Bacterial | 1089 | 1.27 (1.03, 1.56) | 1.1 (0.9, 1.4) | 1.1 (0.6, 2.3) | 0.7 (0.6, 0.8) |
| Viral | 130 | 1.21 (0.69, 2.11) | 1.0 (0.5, 1.8) | 1.1 (0.2, 8.2) | 0.8 (0.5, 1.2) |
| Fungal | 37 | 2.73 (0.66, 11.21) | 0.7 (0.2, 2.2) | 2.8 (0.4, 21.5) | 1.5 (0.8, 3.0) |
| Unknown | 1383 | 1.18 (0.98, 1.41) | 1.0 (0.8, 1.3) | 1.3 (0.7, 2.5) | 0.9 (0.8, 1.1) |
| By site: | |||||
| Pneumonia | 1337 | 1.27 (1.05, 1.53) | 1.1 (0.9, 1.4) | 1.1 (0.5, 2.3) | 1.0 (0.8, 1.1) |
| CNS | 20 | 1.07 (0.30, 3.76) | 1.1 (0.3, 4.2) | * | 0.6 (0.2, 2.0) |
| Abdominal | 61 | 1.07 (0.52, 2.21) | 0.7 (0.3, 2.0) | * | 0.3 (0.2, 0.8) |
| Bone/joint | 206 | 1.95 (1.10, 3.47) | 1.6 (1.0, 2.4) | 2.6 (0.8, 8.7) | 0.6 (0.4, 0.8) |
| Urinary | 85 | 0.62 (0.37, 1.05) | 0.3 (0.1, 1.3) | 2.0 (0.3, 15.4) | 1.1 (0.6, 2.3) |
| Skin | 542 | 1.03 (0.77, 1.38) | 1.0 (0.7, 1.4) | 1.2 (0.5, 2.9) | 0.6 (0.5, 0.8) |
| Sepsis/blood | 420 | 1.40 (1.00, 1.96) | 0.9 (0.7, 1.4) | 0.7 (0.2, 2.6) | 0.8 (0.6, 1.0) |
| Unknown | 89 | 2.01 (0.91, 4.42) | 0.7 (0.3, 1.5) | 2.9 (0.7, 12.1) | 1.5 (0.9, 2.3) |