Table 1

	N	Respiratory morbidity	Respiratory mortality

		HR [95% CI]	HR [95% CI]

Age	942	1.03 [1.01–1.04]	1.10 [1.06–1.14]
Female	942	0.69 [0.52–0.92]	0.28 [0.14–0.56]
Ex–smoker	856	2.06 [1.36–3.11]	4.14 [1.42–12.02]
Current smoker	856	2.68 [1.73–4.13]	3.34 [1.05–10.64]
BMI	921	0.98 [0.95–1.01]	0.91 [0.84–0.98]
DAS 28 score	778	1.33 [1.18–1.50]	1.01 [0.76–1.34]
HAQ score	927	1.68 [1.40–2.01]	1.54 [1.01–2.34]
RF +ve	855	1.55 [1.14–2.11]	1.89 [0.93–3.86]
ACPA +ve	791	1.24 [1.03–1.49]	1.39 [1.00–1.94]
Nodules	941	1.32 [0.75–2.31]	2.14 [0.76–6.06]
Shared epitope	538	1.31 [0.88–1.96]	0.66 [0.26–1.66]

N, number of patients with available data; RF, rheumatoid factor; ACPA, anti-citrullinated protein antibody; CRP, C-reactive protein; HAQ, health assessment questionnaire; HR, hazard ratio.