Adjusted hazard ratios for myocardial infarction among spondyloarthropathy patients treated with diclofenac, naproxen or rofecoxib
| Drug | Use | Subjects | MI | Follow-up time | MI Incidence rate | Crude IRR | Age-sex adjusted HR | Multivariable adjusted HR+ |
|---|---|---|---|---|---|---|---|---|
| (N) | (N) | (PY) | (per 1000 PY) | (95% CI) | (95% CI) | (95% CI) | ||
| Diclofenac | No | 4315 | 46 | 21409.56 | 2.15 | 1.0 | 1.0 | 1.0 |
| Yes | 3480 | 63 | 23148.63 | 2.72 | 1.25 (0.86,1.84) | 1.42 (0.97,2.08) | 1.61 (1.08,2.40) | |
| Naproxen | No | 5619 | 81 | 33821.97 | 2.39 | 1.0 | 1.0 | 1.0 |
| Yes | 2176 | 28 | 9822.65 | 2.85 | 1.20 (0.78,1.85) | 1.25 (0.81,1.92) | 1.40 (0.90,2.19) | |
| Rofecoxib | No | 1415 | 20 | 10998.91 | 1.82 | 1.0 | 1.0 | 1.0 |
| Yes | 527 | 18 | 4290.69 | 4.20 | 2.34 (1.24,4.43) | 2.04 (1.08,3.88) | 2.60 (1.30,5.22) | |
MI, myocardial infarction; PY, person-years. +Adjusted for age, sex, SpA type, BMI, smoking, alcohol, diabetes, hypertension, history of gastrointestinal bleeding, and use of aspirin, ACE inhibitors, beta-blockers, lipid lowering drugs and steroids.