Table 1

		Week 4/6			Week 12/18			Week 24
		wES^*	# studies/# pts	Sample size	wES	# studies/# pts	Sample size	wES	# studies/# pts	Sample size

Synovitis	B vs. DP	NA	3/113	NA	−0.59	5/807	46	−0.26	2/552	230
	BD vs. DP	−1.74^**		6	−0.82		24	−0.69		34
Osteitis	B vs. DP	NA	3/113	NA	−0.60	5/807	44	−0.41	2/558	96
	BD vs. DP	−0.87		22	−0.62		41	−0.59		46
Erosions	B vs. DP	NA	−	NA	0.04	5/807	NA	0.19	3/776	451
	BD vs. DP	Data unsuitable for meta-analysis (high inter-rater variability)			−0.09		1986	−0.06		4075

↵* Weighted Effect size (wES) = (w) mean intervention(s) − (w) mean control/(w) SD intervention and reference.
↵** Driven by 1/3 studies with median (range) synovitis decrease: 13.0 (7.0–14.0) to 9.0 (5.0–12.0). B, biologic; DP, DMARD-placebo; NA, not available/not applicable.