Table 1.

Selected efficacy endpoints at Week 12

Efficacy	PBO	1 mg QD	2 mg QD	4 mg QD	8 mg QD

	(N=49)	(N=24)	(N=24)	(N=24)	(N=24)

% ACR20^*	31	67^‡	83^‡	67^‡	88^‡
% ACR50^*	8	33^‡	46^‡	50^‡	54^‡
% DAS28-CRP <2.6^†	22	29	33	38	38
% DAS28-CRP <3.2^†	31	50	63^‡	67^‡	79^‡
% SDAI ≤3.3^†	8	4	29^‡	17	17
% HAQ-DI ≤0.5^†	45	50	54	63	83^‡
% Pts achieving improvement from baseline of ≥0.22 (MCID)	29	54^‡	58^‡	75^‡	71^‡

1-sided Fisher's exact test.
↵* Non-responder imputation;
↵† last observation;
↵‡ p<0.05 vs. PBO.