Table 1. Odds ratios (95% Confidence Intervals) and P values for Predicting Stable DAS28<3.2 Target and Long-term BFDC by Multivariate Logistic Regression
| Explanatory Variable | Stable Target at Wk 22 & 26 | Stable Target at Wk 52, 66, & 78 | |
|---|---|---|---|
| PBO+MTX | ADA+MTX | ADA+MTX[R]→PBO+MTX | |
| BL MDGA | 0.99 (0.97, 1.00) | n.i. | 0.92 (0.87, 0.97) |
| P=0.04 | P=0.002 | ||
| Joint erosions at BL (no vs. yes) | n.i. | n.i. | 0.19 (0.03, 1.20) |
| P=0.08 | |||
| Wk 12 SJC66 | 0.84 (0.79, 0.90) | 0.88 (0.84, 0.93) | 0.81 (0.65, 1.01) |
| P<0.001 | P<0.001 | P=0.06 | |
| Wk 12 PtGA | 0.97 (0.95, 0.98) | 0.95 (0.94, 0.96) | n.i. |
| P<0.001 | P<0.001 | n.i. | |
| Wk 12 CRP | n.i. | 0.97 (0.94, 1.00) | n.i. |
| P=0.03 | |||
| Wk 26 CRP (Tertiles: 1 [0-2 mg/L] vs 3 [>4 mg/L]) | n.i. | n.i. | 45.1 (6.19, 328.5) |
| P=0.007 | |||
[R], responder for DAS28 <3.2 at wks 22 & 26; n.i., not included in model.