Table 1. Allelic variants associated with non response to anti-TNF-alpha treatment according to BASDAI50 response criteria

Snp	Gene	Risk Allele	OR non-responder	P-adjusted*
			(95% CI)^a
rs755622	MIF	G	2.92 (1.41–6.03)	0.003
rs917997	IL18RAP	A	2.4 (1.32–4.35)	0.005
rs1061622	TNFRSF1B	C	2.12 (1.15–3.91)	0.009
rs4343	ACE	G	1.82 (1.05–3.13)	0.016
rs4355801	TNFRSF11B	A	1.79 (1.04–3.08)	0.051
rs6060369	UQCC	A	1.77 (1.03–3.02)	0.032
rs3740691	ARFGAP2	A	1.76 (1.03–3.02)	0.031
rs331377	ASPN	G	1.7 (1.01–2.84)	0.043
rs3213718	CALM1	A	1.72 (1.01–2.92)	0.044
rs1800896	IL10	A	1.69 (1.01–2.84)	0.029

*p adjusted using single value permutation testing; ^a)P values and Odds Ratios (95% CI) were obtained from Chi-squared test of 2×2 tables of allele frequencies in non-responders versus responders.