Variable | Plasma Chloroquine concentrations, ng/ml | Plasma desethylchloroquine concentrations, ng/ml | ||||
---|---|---|---|---|---|---|
B | 95% CI | p value | B | 95% CI | p value | |
Average CQ dosage (mg/kg-IBW/day) | 7.09 | 0.73, 13.45 | 0.029 | 2.63 | -0.45, 5.70 | 0.093 |
Current CQ dose (mg/kg-IBW/day) | 42.82 | 33.71, 51.94 | <0.0001 | 16.60 | 11.81, 21.39 | <0.0001 |
CQ duration (month) | -0.36 | -0.55, -0.16 | <0.0001 | -0.17 | -0.26, -0.07 | 0.001 |
Cumulative CQ dosage (gm) | -0.05 | -0.11, 0.01 | 0.102 | -0.03 | -0.06, 0.00 | 0.066 |
Age (year) | 0.33 | -0.64, 1.31 | 0.502 | 0.37 | -0.10, 0.84 | 0.121 |
CCl (ml/min/1.73 m2) | -0.11 | -0.65, 0.43 | 0.7 | -0.03 | -0.29, 0.24 | 0.836 |
BMI (kg/m2) | -0.38 | -7.23, -0.45 | 0.027 | -1.20 | -2.87, 0.47 | 0.158 |
Note: CQ = chloroquine, IBW = ideal body weight, CCl = creatinine clearance, BMI = body mass index; Beta = standardized coefficient.