Outcomes	Number of comparisons	Number of patients	RR [95% CI]	Quality of the Evidence
Diabetes	17	1530	1.26 [0.58, 2.73]	Moderate
Osteoporosis	11	1114	1.41 [0.79, 2.53]	Low
Cardiovascular disease	19	1944	0.91 [0.60, 1.38]	Moderate
Hypertension	21	2178	1.24 [0.83, 1.86]	Moderate
Infections	20	2296	0.90 [0.78, 1.04]	Moderate
Renal Dysfunction	15	2044	1.56 [1.09, 2.22]	Low
Weight gain	17	1897	1.21 [0.98, 1.48]	Low
Cushingoid changes	17	1534	1.09 [0.73, 1.61]	Low
Withdrawal from study	52	4471	0.77 [0.65, 0.92]	Low
Withdrawal due to AE	40	3573	1.23 [0.96, 1.57]	Moderate