Results of analyses on the primary outcome: joint space width change measured on anteroposterior pelvis or target hip views using manual radiochondrometry, and rate of progressors, at 3 years, in the full analysis set, according to the MAR-MMRM analysis model
| Placebo (n=179) | ASU-E (n=166) | p Value | OR/Diff | 95% CI | |
|---|---|---|---|---|---|
| Change in JSW at the narrowest point (mm) (mean (SEM)) | −0.672 (0.066) | −0.638 (0.070) | 0.723* | 0.034 (0.096) | −0.156 to 0.224 |
| Progressors (progressor=JS loss≥0.5 mm at 3 years) (%) | 50.3 | 40.4 | 0.040† | 1.613 | 1.023 to 2.543 |
*ANOVA treatment effect.
†Cochran–Mantel–Haenzel test adjusted on stratum.
ASU-E, avocado–soybean unsaponifiable—Expanscience; JSW, joint space width; MAR-MMRM, Missing at Random–Mixed Model for Repeated Measurements; OR, odds ratio ASU-E versus placebo.