Table 1. Frequency of clinical, laboratory, histopathologic features of 270 patients with MAS

FeaturePercentage
Falling platelet count (≤262×109/l)72.6
Hyperferritinemia (≥500 ng/ml)91.1
Bone marrow hemophagocytosis63
Increased liver enzymes (AST>59UI/L)72
Falling leukocyte count (<4×109/l)21.8
Persistent continuous fever ≥38°C61.7
Hypofibrinogenemia (≤2,5 g/l)52.7
Hypertrigliceridemia (≥265 mg/dl)45.8
Central nervous system dysfunction35.7
Increased D-dimer (≥500 ng/ml)58.2
Hemorrhagic manifestations19.8
Liver enlargement70.7
Spleen enlargement62.3